Evaluation of Gas6 and sAxl levels during attacks and attack-free periods of familial Mediterranean fever

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dc.contributor.authorCakirca, Gokhan
dc.contributor.authorCelik, Muhammet Murat
dc.date.accessioned2024-09-18T20:20:00Z
dc.date.available2024-09-18T20:20:00Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives: We aimed to assess the growth arrest specific protein 6 (Gas6) and soluble Axl (sAxl) levels in the familial Mediterranean fever (FMF) patients, and to investigate the correlation between the levels of these with the inflammatory markers including C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and fibrinogen. Materials and methods: Seventy nine FMF patients (35 in attack period and 44 in attack-free period) and 40 healthy controls were involved in the study. The levels of serum Gas6 and sAxl were measured by enzyme-linked immuno-sorbent assay (ELISA) method. Results: Gas6 levels of the FMF patients with attack were significantly lower than both the attack-free patients and the healthy controls (p = 0.007 and p = 0.003, respectively). However, no significant difference was detected between the Gas6 levels of the attack-free patients and the healthy controls (p > 0.05). sAxl levels of the FMF patients with attack were significantly lower than the healthy control (p = 0.007). A positive correlation was found between the Gas6 and CRP levels of the FMF patients with attack (r = 0.379, p = 0.025). Conclusions: This study indicates that decreased serum Gas6 and sAxl levels may be associated with FMF attack period. Further studies on the role of the Gas6/Axl system in FMF are needed.en_US
dc.description.sponsorshipCoordination Office of Scientific Research Projects in Mustafa Kemal University [15436]en_US
dc.description.sponsorshipThis work was supported by the Coordination Office of Scientific Research Projects in Mustafa Kemal University [No: 15436].en_US
dc.identifier.doi10.1515/tjb-2017-0227
dc.identifier.endpage480en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85041198763en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage475en_US
dc.identifier.urihttps://doi.org/10.1515/tjb-2017-0227
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10005
dc.identifier.volume43en_US
dc.identifier.wosWOS:000449635800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFamilial Mediterranean feveren_US
dc.subjectGrowth arrest specific 6en_US
dc.subjectTyrosine kinase receptoren_US
dc.subjectInflammationen_US
dc.subjectApoptosisen_US
dc.titleEvaluation of Gas6 and sAxl levels during attacks and attack-free periods of familial Mediterranean feveren_US
dc.typeArticleen_US

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