Utilization of statins and LDL-cholesterol target attainment in Turkish patients with type 2 diabetes-a nationwide cross-sectional study (TEMD dyslipidemia study)

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dc.authoridCETIN, SEDAT/0000-0002-6937-0865
dc.authoridAsik, mehmet/0000-0002-0716-0221
dc.authoridDizdar, Oguzhan/0000-0001-9259-7024
dc.authoridayturk, semra/0000-0002-1560-3459
dc.authoridkirac, cem onur/0000-0002-0249-9867
dc.authoridYildiz, Bulent/0000-0003-1797-7662
dc.authoridGONEN, MUSTAFA SAIT/0000-0002-1089-623X
dc.contributor.authorBayram, Fahri
dc.contributor.authorSonmez, Alper
dc.contributor.authorHaymana, Cem
dc.contributor.authorSabuncu, Tevfik
dc.contributor.authorDizdar, Oguzhan Sitki
dc.contributor.authorGurkan, Eren
dc.contributor.authorCarlioglu, Ayse Kargili
dc.date.accessioned2024-09-18T20:16:35Z
dc.date.available2024-09-18T20:16:35Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground Attaining acceptable levels of LDL Cholesterol (LDL-C) significantly improves cardiovascular (CV) outcomes in patients with type 2 diabetes mellitus (T2DM). The LDL-C target attainment and the characteristics of patients attaining these targets were investigated in this study. Furthermore, the reasons for not choosing statins and the physicians' attitudes on the treatment of diabetic dyslipidemia were also examined. Methods A nationwide, cross-sectional survey was conducted in tertiary centers for diabetes management. Adult patients with T2DM, who were under follow-up for at least a year in outpatient clinics, were consecutively enrolled for the study. LDL-C goals were defined as below 70 mg/dL for patients with macrovascular complications or diabetic nephropathy, and below 100 mg/dL for other patients. Data about lipid-lowering medications were self-reported. Results A total of 4504 patients (female: 58.6%) were enrolled for the study. The mean HbA1c and diabetes duration was 7.73 +/- 1.74% and 10.9 +/- 7.5 years, respectively. The need for statin treatment was 94.9% (n = 4262); however, only 42.4% (n = 1807) of these patients were under treatment, and only 24.8% (n = 448) of these patients achieved LDL-C targets. The main reason for statin discontinuation was negative media coverage (87.5%), while only a minority of patients (12.5%) mentioned side effects. Physicians initiated lipid-lowering therapy in only 20.3% of patients with high LDL-C levels. It was observed that the female gender was a significant independent predictor of not attaining LDL-C goals (OR: 0.70, 95% CI: 0.59-0.83). Conclusions Less than 50 % of patients with T2DM who need statins were under treatment, and only a quarter of them attained their LDL-C targets. There exists a significant gap between the guideline recommendations and the real-world evidence in the treatment of dyslipidemia in T2DM.en_US
dc.description.sponsorshipSociety of Endocrinology and Metabolism of Turkey [04/10/2016-01]en_US
dc.description.sponsorshipThe TEMD study has been funded by the Society of Endocrinology and Metabolism of Turkey (Grant no. 04/10/2016-01). Automated BP monitors were provided by Sanovel A/S. The funding agencies had no role in the design and conduct of the study; the collection, management, analysis and interpretation of the data; or the preparation, review or approval of the manuscript.en_US
dc.identifier.doi10.1186/s12944-020-01408-2
dc.identifier.issn1476-511X
dc.identifier.issue1en_US
dc.identifier.pmid33176832en_US
dc.identifier.scopus2-s2.0-85095847674en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1186/s12944-020-01408-2
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9618
dc.identifier.volume19en_US
dc.identifier.wosWOS:000588694500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofLipids in Health and Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDyslipidemiaen_US
dc.subjectType 2 diabetes mellitusen_US
dc.subjectLipid-lowering treatmentsen_US
dc.subjectPhysicians’ attitudesen_US
dc.subjectLow-density lipoprotein cholesterol target attainmenten_US
dc.subjectStatin cessationen_US
dc.subjectPhysician inertiaen_US
dc.titleUtilization of statins and LDL-cholesterol target attainment in Turkish patients with type 2 diabetes-a nationwide cross-sectional study (TEMD dyslipidemia study)en_US
dc.typeArticleen_US

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