Effects of L-arginine and N?-nitro-L-arginine methyl ester on lipid peroxidation and antioxidant enzymes to liver of rats with ductus choledochus ligation

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dc.authorscopusid36866111300
dc.authorscopusid6701664660
dc.authorscopusid6701808364
dc.authorscopusid6603854264
dc.contributor.authorGürel, Ahmet
dc.contributor.authorArmutcu, Ferah
dc.contributor.authorSö?üt, Sadik
dc.contributor.authorCihan, Alper
dc.date.accessioned2024-09-19T15:43:44Z
dc.date.available2024-09-19T15:43:44Z
dc.date.issued2003
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOne of the most important reasons of liver destruction in obstructive jaundice is reactive oxygen derived compounds which are formed as a result of demolished liver circulation. In this experimental study, we investigated the effects of L-arginine and L-NAME on liver antioxidant system and lipid peroxidation in rats after ductus choledochus ligation (BDL). For this purpose, fifteen rats were divided randomly into three equal groups. BDL group (n=5): bile duct ligation was performed in rats. L-Arginine group (n=5): Anaesthetized rats were given L-arginine (1 mg/kg) for 7 days after BDL. L-NAME group (n=5): Anaesthetized rats were given L-NAME (2 mg/kg) for 7 days after BDL. Liver tissue was removed in all rats under anesthesia seven days after surgical procedure. Tissue was homogenized and malondialdehyde (MDA) and nitric oxide levels, xanthine oxidase, superoxide dismutase (SOD) and catalase (CAT) levels were studied in the homogenate. Liver tissue MDA level of L-arginine group was significantly lower than control and L-NAME groups. Activity of SOD in L-arginine group was significantly lower than L-NAME and BDL groups. Activitiy of CAT and level of NO in L-arginine group were significantly lower than those of L-NAME group. Liver tissue MDA level of L-NAME group was significantly higher than BDL group. These findings show that L-arginine treatment is effective in prevention of oxidative liver destruction as a result of bile duct obstruction.en_US
dc.identifier.endpage192en_US
dc.identifier.issn1300-2996
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-11844299061en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage186en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14538
dc.identifier.volume20en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofOndokuz Mayis Universitesi Tip Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBile duct ligationen_US
dc.subjectLiveren_US
dc.subjectNitric oxideen_US
dc.subjectOxidant stressen_US
dc.titleEffects of L-arginine and N?-nitro-L-arginine methyl ester on lipid peroxidation and antioxidant enzymes to liver of rats with ductus choledochus ligationen_US
dc.title.alternativeKoledok kanali tikanikli?i yapilan ratlarda L-arjinin ve N ?-nitro-L-arjinin metil ester tedavisinin karaci?er dokusu lipit peroksidasyonu ve antioksidan enzimler üzerine etkisien_US
dc.typeArticleen_US

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