Investigation of thiol/disulfide homeostasis in familial mediterranean fever patients

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dc.authoridneselioglu, salim/0000-0002-0974-5717
dc.contributor.authorCakirca, Gokhan
dc.contributor.authorCelik, Muhammet Murat
dc.contributor.authorErdal, Huseyin
dc.contributor.authorNeselioglu, Salim
dc.contributor.authorErel, Ozcan
dc.contributor.authorBasarali, Mustafa Kemal
dc.contributor.authorCakirca, Tuba Damar
dc.date.accessioned2024-09-18T20:20:01Z
dc.date.available2024-09-18T20:20:01Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim: To determine the thiol/disulfide homeostasis in patients with familial Mediterranean fever (FMF) and its correlation with the levels of inflammatory markers consisting of white blood cell count, erythrocyte sedimentation rate, C-reactive protein and fibrinogen. Material and Method: This study was performed in the internal Medicine department of Mustafa Kemal University Hospital in Turkey. A total of 27 FMF patients in the attack period (AP), 33 FMF patients in the attack-free period (AFP), and 36 healthy controls participated in this study. Thiol/disulfide profile parameters were detected using the novel method of Erel and Neselioglu. Results: Total and native thiol levels of the FMF-AP group were markedly lower than those of healthy controls, while the difference in disulfide level was not statistically significant. Thiol/disulfide levels in the FMF-AFP group were similar to the levels in both the FMF-AP group and healthy controls. Correlation analysis showed a negative correlation between fibrinogen levels and total and native thiol levels, while there was a positive correlation between white blood cell count and disulfide levels in the FMF-AP group. Discussion: The findings suggest that decreased concentrations of total and native thiol in patients with FMF-AP are likely to be an outcome of inflammation-induced oxidative stress.en_US
dc.identifier.doi10.4328/JCAM.5789
dc.identifier.endpage234en_US
dc.identifier.issn1309-0720
dc.identifier.issn1309-2014
dc.identifier.issue3en_US
dc.identifier.startpage231en_US
dc.identifier.urihttps://doi.org/10.4328/JCAM.5789
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10008
dc.identifier.volume9en_US
dc.identifier.wosWOS:000429961400012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherDerman Medical Publen_US
dc.relation.ispartofJournal of Clinical and Analytical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFamilial Mediterranean Feveren_US
dc.subjectThiolen_US
dc.subjectDisulfideen_US
dc.subjectOxidative Stressen_US
dc.subjectInflammationen_US
dc.titleInvestigation of thiol/disulfide homeostasis in familial mediterranean fever patientsen_US
dc.typeArticleen_US

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