Association of childhood obesity with retinal microvasculature and corneal endothelial cell morphology

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dc.contributor.authorKurtul, Bengi Ece
dc.contributor.authorCakmak, Ayse Idil
dc.contributor.authorElbeyli, Ahmet
dc.contributor.authorKaraaslan, Abdulkerim
dc.contributor.authorEl, Cigdem
dc.date.accessioned2024-09-18T20:08:16Z
dc.date.available2024-09-18T20:08:16Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives: To investigate the optical coherence tomography angiography (OCTA) and specular microscopy (SM) findings in obese children and compare them with healthy ones. Methods: In this prospective study, 50 eyes of 25 obese children [body mass index (BMI) >= 95th percentile], 36 eyes of 18 control age- and sex- matched healthy subjects (BMI <85th percentile) were included. Demographic features and ophthalmological examination including OCTA measurements as well as SM findings were assessed. Cellular morphology was observed by noncontact SM and results for corneal endothelial cell density (cells/mm(2)), coefficient of variation of cell size and percentage of hexagonal cells were obtained. The OCTA was performed with 6 x 6 mm sections for macula and 4.5 x 4.5 mm sections for optic disc in all eyes. Foveal retinal thickness (FRT), retinal nerve fiber layer (RNFL) thickness, vessel density in different sections of retina and optic nerve head were analyzed. Results: All SM parameters, RNFL thickness for average, and all quadrants and optic disc radial peripapillary capillary densities were similar between groups. However, FRT, flow area for choriocapillaris, superficial and deep foveal capillary densities were significantly higher in obese group when compared to controls (242.4 +/- 18.2 mu m vs. 232.1 +/- 16.5 mu m, p=0.024, 2.2 +/- 0.1 mm(2) vs, 2.2 +/- 0.0 mm(2), p=0.042, 22.4 +/- 6.9% vs. 15.6 +/- 5.5%, p=0.001, and 38.9 +/- 7.5% vs. 31.1 +/- 8.6 %, p=0.001, respectively). Conclusions: Obese children seem to have higher values of FRT, flow area for choriocapillaris, superficial and deep foveal capillary densities. These results may have significant implications for understanding of how childhood obesity could affect retinal microvasculature.en_US
dc.identifier.doi10.1515/jpem-2020-0483
dc.identifier.endpage176en_US
dc.identifier.issn0334-018X
dc.identifier.issn2191-0251
dc.identifier.issue2en_US
dc.identifier.pmid33544543en_US
dc.identifier.scopus2-s2.0-85097866217en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage171en_US
dc.identifier.urihttps://doi.org/10.1515/jpem-2020-0483
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8745
dc.identifier.volume34en_US
dc.identifier.wosWOS:000626401500003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofJournal of Pediatric Endocrinology & Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchildhood obesityen_US
dc.subjectcornea endotheliumen_US
dc.subjectoptical coherence tomography angiographyen_US
dc.subjectretinal microvasculatureen_US
dc.subjectspecular microscopyen_US
dc.titleAssociation of childhood obesity with retinal microvasculature and corneal endothelial cell morphologyen_US
dc.typeArticleen_US

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