The Antipsychotic Effects of Omega-3 Fatty Acids in Rats

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dc.authoridDokuyucu, Recep/0000-0001-7881-8871
dc.authoridDokuyucu, Recep/0000-0001-6837-3477
dc.authoridErbas, Oytun/0000-0001-5427-8428
dc.contributor.authorKokacya, Mehmet Hanifi
dc.contributor.authorInanir, Sema
dc.contributor.authorCopoglu, Umit Sertan
dc.contributor.authorDokuyucu, Recep
dc.contributor.authorErbas, Oytun
dc.date.accessioned2024-09-18T21:05:11Z
dc.date.available2024-09-18T21:05:11Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: In humans, omega-3 fatty acids are necessary for cell membranes, brain function and nerve transmission continuation. When animals are exposed to a new environment-or as a result of an apomorphine application that creates an agonistic effect on D1 and D2 receptors-they display behavioral reactions like rearing and stereotypy. This study aims to reveal the possible antipsychotic and oxidative effects of omega-3 fatty acids by comparing with chlorpromazine, a conventional antipsychotic drug, through evaluating the novelty-induced rearing and apomorphine-induced stereotypic behaviors, as well as malondialdehyde and glutathione levels in rats. Methods: Twenty-eight, adult, male, Wistar rats were used in the study. Briefly, 4 groups of rats (n = 7) were administered docosahexaenoic acid (DHA) + eicosapentaenoic acid (EPA) (300 mg/kg; DHA: 120 mg/kg + EPA: 180 mg/kg intraperitoneally [IP]), DHA + EPA (150 mg/kg; DHA: 60 mg/kg + EPA: 90 mg/kg IP), chlorpromazine (1 mg/kg, IP) and isotonic saline (1 mL/kg, IP). One hour later, apomorphine (2 mg/kg, subcutaneously) was administered to each rat. After the apomorphine administration, rats were observed for stereotypic behavior. Results: This study shows that omega-3 fatty acids, similar to antipsychotics, reversed the psychotic like effects, increase of oxidants and decrease of antioxidants that are composed experimentally in rats. Conclusions: The application of omega-3 fatty acids has antipsychotic effects and causes an oxidative imbalance. This study adds new evidence to the current literature regarding the possible antipsychotic effects of omega-3 fatty acids.en_US
dc.identifier.doi10.1097/MAJ.0000000000000531
dc.identifier.endpage217en_US
dc.identifier.issn0002-9629
dc.identifier.issn1538-2990
dc.identifier.issue3en_US
dc.identifier.pmid26200950en_US
dc.identifier.scopus2-s2.0-84941133103en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage212en_US
dc.identifier.urihttps://doi.org/10.1097/MAJ.0000000000000531
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13434
dc.identifier.volume350en_US
dc.identifier.wosWOS:000360817700010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofAmerican Journal of The Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPlacebo-Controlled-Trialen_US
dc.subjectEthyl-Eicosapentaenoic Aciden_US
dc.subjectOxidative Stressen_US
dc.subjectFatty-Acidsen_US
dc.subjectAtypical Antipsychoticsen_US
dc.subjectSchizophrenic-Patientsen_US
dc.subjectDopamine-Receptorsen_US
dc.subjectBipolar Disorderen_US
dc.subjectSupplementationen_US
dc.subjectPreventionen_US
dc.titleThe Antipsychotic Effects of Omega-3 Fatty Acids in Ratsen_US
dc.typeArticleen_US

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