Expression patterns and distribution of aquaporin water channels in cervix as a possible mechanism for cervical patency in bitches affected by pyometra

Basit Öğe Kaydı
dc.authoridKaya, Ufuk/0000-0002-4805-0993
dc.authoridOzoner, Ozgur/0000-0001-7354-0655
dc.authoridOzkan, Huseyin/0000-0001-5753-8985
dc.contributor.authorYazlik, Murat Onur
dc.contributor.authorOzkan, Hueseyin
dc.contributor.authorVural, Sevil Atalay
dc.contributor.authorKaya, Ufuk
dc.contributor.authorOzoner, Ozgur
dc.contributor.authorMutluer, Ipek
dc.contributor.authorAltinbas, Yunus Furkan
dc.date.accessioned2024-09-18T20:02:36Z
dc.date.available2024-09-18T20:02:36Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPyometra is a life-threatening disease, the severity of which depends on cervical patency status. This study investigated cervical inflammation status as well as the expression patterns and localization of aquaporin (AQP1, AQP2, AQP3, AQP5, and AQP9), and hormone receptors in cervical tissue that influences canine pyometra. Of the 36 animals enrolled in the study, 24 were diagnosed with pyometra and separated into two groups: open cervix pyometra and close cervix pyometra, while 12 healthy animals presented for elective ovariohysterectomies were allocated into the control group. Surgical treatment was performed for treatment of pyometra. After each operation, cervix samples were collected and analyzed for AQP and hormone receptor expression patterns determined by qPCR and protein expression by means of immunohistochemistry. Blood samples were also collected to determine serum progesterone concentrations. AQP9 expression was downregulated approximately 3-fold while and PGR expression was downregulated more than 2 fold in both pyometra groups compared to the control group. AQP3 and AQP5 gene expression levels were upregulated more than 3 fold in the open-cervix pyometra group than the closed-cervix pyometra group (P < 0.05). This is the first study to describe the expression patterns and immunolocalization of AQPs in canine cervical tissue based on pyometra patency status and to report AQP3 and AQP5 expression in cervical tissue linked to cervical patency.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkiye (TUBITAK), Turkiye [120O543]en_US
dc.description.sponsorshipThis study was conducted as a project supported by the The Scientific and Technological Research Council of Turkiye (TUBITAK) (Project number: 120O543) , Turkiye.en_US
dc.identifier.doi10.1016/j.theriogenology.2024.07.022
dc.identifier.endpage143en_US
dc.identifier.issn0093-691X
dc.identifier.issn1879-3231
dc.identifier.pmid39067211en_US
dc.identifier.scopus2-s2.0-85199449141en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage138en_US
dc.identifier.urihttps://doi.org/10.1016/j.theriogenology.2024.07.022
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7895
dc.identifier.volume227en_US
dc.identifier.wosWOS:001284212300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTheriogenologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAquaporinen_US
dc.subjectCanineen_US
dc.subjectCervixen_US
dc.subjectPatencyen_US
dc.titleExpression patterns and distribution of aquaporin water channels in cervix as a possible mechanism for cervical patency in bitches affected by pyometraen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
7895.pdf
Boyut:
4.01 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu