The effect of caffeic acid phenethyl ester and thymoquinone on otitis media with effusion in rats

Basit Öğe Kaydı
dc.authoridDokuyucu, Recep/0000-0001-6837-3477
dc.authoridGulmez, Mehmet Ihsan/0000-0003-0462-6353
dc.contributor.authorGulmez, Mehmet Ihsan
dc.contributor.authorOkuyucu, Emsettin
dc.contributor.authorDokuyucu, Recep
dc.contributor.authorGokce, Hasan
dc.date.accessioned2024-09-18T20:53:00Z
dc.date.available2024-09-18T20:53:00Z
dc.date.issued2017
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: In this study, we aimed to investigate the effect of CAPE and thymoquinone in experimental rat otitis media with effusion (OME) model. Methods: Intraoral approach of eustachian tube orifice cauterization were administered to 36 of 40 rats participating the study. After application of exclusion criterias, 22 rats with appropriate conditions were determined. Totally 26 rats (44 otitis model ears and 8 normal ears) were randomly divided into 5 groups. While group I was consisted of healthy rats, the other groups were consisted of rats with otitis model. Group I (saline + control group; n = 8 normal ears) and group II (saline + otitis model; n = 10 otitis model ears) received intraperitoneally saline solution. CAPE was given intraperitoneally to group III (CAPE + otitis model; n = 12 otitis model ears) at a concentration of 10 mg/kg for treatment of otitis media. Group IV (thymoquinone + otitis model; n = 12 otitis model ears) was treated orally with 10 mg/kg of thymoquinone. Group V (methylprednisolone + otitis model; n = 10 otitis model ears) was treated intraperitoneally with 1 mg/kg of methylprednisolone. Tympanic bulla samples were excised after 10th day of treatment and examined under light microscopy. Results: Submucosal neutrophil leukocyte count of group 1 was significantly lower than other groups (II, IV, V) (respectively p < 0,0001, p < 0,001, p < 0,0001, Tukey test), while it was not significantly different from group III (p = 0,056, Tukey test). Submucosal neutrophil leukocyte count of group III was significantly lower than group II and group V (p = 0.029 ve p = 0.03, Tukey test). There was no significant difference between group IV and group V (p = 0,28, Tukey test). Conclusion: Based on these findings, it could be suggested that CAPE, anti inflammatory properties proven in the literature, plays an important role in OME treatment. (C) 2017 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijporl.2017.03.011
dc.identifier.endpage99en_US
dc.identifier.issn0165-5876
dc.identifier.issn1872-8464
dc.identifier.pmid28390622en_US
dc.identifier.scopus2-s2.0-85015032119en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage94en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijporl.2017.03.011
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11528
dc.identifier.volume96en_US
dc.identifier.wosWOS:000403737800019en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofInternational Journal of Pediatric Otorhinolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOtitis media with effusionen_US
dc.subjectCaffeic acid phenyl esteren_US
dc.subjectThymoquinoneen_US
dc.subjectInflammationen_US
dc.titleThe effect of caffeic acid phenethyl ester and thymoquinone on otitis media with effusion in ratsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
Tam Metin / Full Text
Boyut:
1.05 MB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu