Prognostic Significance of Neutrophil Gelatinase-Associated Lipocalin in ST-Segment Elevation Myocardial Infarction

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dc.contributor.authorAkcay, Adnan Burak
dc.contributor.authorOzlu, Mehmet Fatih
dc.contributor.authorSen, Nihat
dc.contributor.authorCay, Serkan
dc.contributor.authorOzturk, Oktay Hasan
dc.contributor.authorYalicn, Fatih
dc.contributor.authorBilen, Perihan
dc.date.accessioned2024-09-18T20:59:09Z
dc.date.available2024-09-18T20:59:09Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives: This study investigated the prognostic value of neutrophil gelatinase-associated lipocalin (NGAL) in patients with ST-segment elevation myocardial infarction (STEMI). Background: Neutrophil gelatinase-associated lipocalin is a promising biomarker for acute kidney injury. Recently, it was concluded that NGAL may be used beyond the boundaries of renal physiopathology. It was found to be an important factor indirectly contributing to the inflammatory processes. Little is known regarding its predictive role in STEMI. Methods: One hundred six consecutive patients who underwent percutaneous coronary intervention (PCI) for STEMI and control group consisted of age- and sex-matched 60 consecutive patients with chest pain admitted to the hospital for elective PCI. According to median NGAL level, patients were classified into high-and low-NGAL groups. Results: Neutrophil gelatinase-associated lipocalin levels were higher in patients with STEMI compared to the elective PCI group subjects. Inhospital and 1-year mortality rates were found to be significantly greater in patients with high NGAL. In addition, inhospital and 1-year major adverse cardiovascular event rates were significantly greater in the high-NGAL group, compared to the low NGAL group. High NGAL level on admission was a significant predictor for long-term mortality and major adverse cardiovascular events. The receiver operating characteristics curve analysis further illustrated that NGAL level on admission is a strong indicator of mortality, with an area under the curve of 0.76 (95% confidence interval, 0.62-0.89). Conclusions: High NGAL levels may be associated with poor prognosis after PCI in patients with STEMI. However, further studies with larger numbers of patients and longer follow-up are required to evaluate the usefulness of plasma NGAL level for predicting prognosis of STEMI.en_US
dc.identifier.endpage513en_US
dc.identifier.issn1081-5589
dc.identifier.issn1708-8267
dc.identifier.issue2en_US
dc.identifier.pmid22222228en_US
dc.identifier.startpage508en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12410
dc.identifier.volume60en_US
dc.identifier.wosWOS:000299351200007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmj Publishing Groupen_US
dc.relation.ispartofJournal of Investigative Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectST-segment elevation myocardial infarctionen_US
dc.subjectneutrophil gelatinase-associated lipocalinen_US
dc.subjectprognosisen_US
dc.titlePrognostic Significance of Neutrophil Gelatinase-Associated Lipocalin in ST-Segment Elevation Myocardial Infarctionen_US
dc.typeArticleen_US

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