The In Vitro Genotoxic Effects of a Commercial Formulation of ?-Cypermethrin in Human Peripheral Blood Lymphocytes

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dc.contributor.authorKocaman, Ayse Yavuz
dc.contributor.authorTopaktas, Mehmet
dc.date.accessioned2024-09-18T19:52:39Z
dc.date.available2024-09-18T19:52:39Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractalpha-Cypermethrin, a highly active pyrethroid insecticide, is effective against a wide range of insects encountered in agriculture and animal husbandry. The potential genotoxicity of a commercial formulation of (x-cypermethrin (Fastac 100 EC, containing 10% alpha-cypermethrin as the active ingredient) on human peripheral lymphocytes was examined in vitro by sister chromatid exchange (SCIE), chromosomal aberrations (CAs), and micronucleus (MN) tests. The human lymphocytes were treated with 5, 10, 15, and 20 mu g/ml of a-cypermethrin for 24- and 48-hr. alpha-Cypermethrin induced SCEs and CAs significantly at all concentrations and treatment times and MN formation was significantly induced at 5 and 10 mu g/ml of alpha-cypermethrin when compared with both the control and solvent control. Binuclear cells could not be detected sufficiently in the highest two concentration of alpha-cypermethrin (15 and 20 mu g/ml) for both the 24- and 48-hr treatment times. alpha-Cypermethrin decreased the proliferation index (PI) at three high concentrations (10, 15, and 20 mu g/ml) for both treatment periods as compared with the control groups. In addition, alpha-cypermethrin reduced both the mitotic index (MI) and nuclear division index (NDI) significantly at all concentrations for two treatment periods. The PI and MI were reduced by alpha-cypermethrin in a concentration-dependent manner during both treatment times. In general, alpha-cypermethrin showed higher cytotoxic and cytostatic effects than positive control (MMC) at the two highest concentrations for the 24- and 48-hr treatment periods. The present study is the first to report the genotoxic and cytotoxic effects of commercial formulation of a-cypermethrin in peripheral blood lymphocytes. Environ. Mol. Mutagen. 50:27-36, 2009. (C) 2008 Wiley-Liss, Inc.en_US
dc.identifier.doi10.1002/em.20434
dc.identifier.endpage36en_US
dc.identifier.issn0893-6692
dc.identifier.issue1en_US
dc.identifier.pmid19031422en_US
dc.identifier.scopus2-s2.0-58549108802en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage27en_US
dc.identifier.urihttps://doi.org/10.1002/em.20434
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7575
dc.identifier.volume50en_US
dc.identifier.wosWOS:000262564800005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Lissen_US
dc.relation.ispartofEnvironmental and Molecular Mutagenesisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectalpha-cypermethrinen_US
dc.subjecthuman peripheral lymphocytesen_US
dc.subjectsister chromatid exchangeen_US
dc.subjectchromosome aberrationen_US
dc.subjectmicronucleusen_US
dc.titleThe In Vitro Genotoxic Effects of a Commercial Formulation of ?-Cypermethrin in Human Peripheral Blood Lymphocytesen_US
dc.typeArticleen_US

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