Spinal Arachnoiditis and The Axonal Degeneration of The Spinal Nerve Roots Due to Ischemia Induced By Vasospasm: An Experimental Study

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dc.authoridKanat, Ayhan/0000-0002-8189-2877
dc.contributor.authorOnder, Arif
dc.contributor.authorSerarslan, Yurdal
dc.contributor.authorAydin, M. Dumlu
dc.contributor.authorKanat, Ayhan
dc.contributor.authorGursan, Nesrin
dc.contributor.authorYolas, Coskun
dc.date.accessioned2024-09-18T20:02:37Z
dc.date.available2024-09-18T20:02:37Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Ãœniversitesien_US
dc.description.abstractObjective: Various reasons have been ascribed to arachnoiditis development, among which subarachnoid hemorrhage (SAH) may be an important factor in this process. In this experimental study, we investigated the effect of SAH on histopathological findings. The volumetric changes of the radicular arteries and the density of spinal nerve root axons of a SAH model on C-4 roots in rabbits were measured. Materials and Methods: In this study, 18 rabbits were used. The animals were randomly divided into three groups: subarachnoid hemorrhage (SAH; n = 10), physiologic serum (SF; n = 4) and control (n = 4) groups. SAH was performed by injecting 0.5 cc of blood into cisterna magna taken from their auricular veins. Cervical spinal nerve roots at the C-4 level were examined histopathologically. Results: Meningeal thickening and adhesions, reddish spinal cord and radices were detected macroscopically. Histopathologically, leptomeningeal adhesions, intimal lesions of radicular arteries and axonal injury were detected at the nerve radices. The mean radicular artery volume was found to be low on the arachnoiditis developing animals. The mean alive axon density of the C-4 nerve root decreased and axonal degeneration was observed in the SAH group. Conclusion: Our study suggests that SAH may be an important etiologic factor in spinal arachnoiditis.en_US
dc.identifier.endpage423en_US
dc.identifier.issn1302-1664
dc.identifier.issue4en_US
dc.identifier.startpage416en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7909
dc.identifier.volume26en_US
dc.identifier.wosWOS:000273393300006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherJournal Neurological Sciencesen_US
dc.relation.ispartofJournal of Neurological Sciences-Turkishen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArachnoiditisen_US
dc.subjectaxonen_US
dc.subjectnerve rooten_US
dc.subjectsubarachnoid hemorrhageen_US
dc.subjectvasospasmen_US
dc.titleSpinal Arachnoiditis and The Axonal Degeneration of The Spinal Nerve Roots Due to Ischemia Induced By Vasospasm: An Experimental Studyen_US
dc.typeArticleen_US

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