Nitric oxide, lipid peroxidation, and antioxidant enzyme levels in epileptic children using valproic acid

Basit Öğe Kaydı
dc.authoridOktar, Suleyman/0000-0003-0151-5981
dc.contributor.authorPeker, Erdal
dc.contributor.authorOktar, Sueleyman
dc.contributor.authorAn, Mustafa
dc.contributor.authorKozan, Ramazan
dc.contributor.authorDogan, Murat
dc.contributor.authorCagan, Eren
dc.contributor.authorSoeguet, Sadik
dc.date.accessioned2024-09-18T21:00:31Z
dc.date.available2024-09-18T21:00:31Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIn the present study, we investigated the effects of valproic acid (VPA) on nitric oxide (NO) level, lipid peroxidation, and antioxidant enzyme activities in 21 epileptic children and 26 healthy controls. The subjects were selected from those who visited for a checkup or medical treatment at the Mustafa Kemal University Research Hospital. Serum levels of NO-2, NO-3, malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) were analyzed by redox or enzymatic reactions and spectrophotometry. Based on the NO-2 and NO-3 levels, the NO concentration was about 10% higher in VPA group than in the control group (p < 0.001). However, no significant difference was detected for serum MDA, SOD, and CAT levels. It is suggested that NO would play a role in the mechanism of antiepileptic effects by VPA treatment. (c) 2009 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.brainres.2009.08.048
dc.identifier.endpage197en_US
dc.identifier.issn0006-8993
dc.identifier.issn1872-6240
dc.identifier.pmid19703427en_US
dc.identifier.scopus2-s2.0-71749119931en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage194en_US
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2009.08.048
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12741
dc.identifier.volume1297en_US
dc.identifier.wosWOS:000271173200021en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofBrain Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectValproic aciden_US
dc.subjectNitric oxideen_US
dc.subjectAntioxidant enzymeen_US
dc.subjectEpilepsyen_US
dc.subjectChildrenen_US
dc.titleNitric oxide, lipid peroxidation, and antioxidant enzyme levels in epileptic children using valproic aciden_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
Tam Metin / Full Text
Boyut:
146.27 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu