Biomechanical effects of menopause in ovariectomized rats' femurs

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dc.authoridAksakal, Bunyamin/0000-0003-4844-9387
dc.authoridAksakal, B/0009-0007-7644-5785
dc.contributor.authorOkyay, Ayse Guler
dc.contributor.authorKavak, Servet
dc.contributor.authorTurktas, Ugur
dc.contributor.authorAlkis, Ismet
dc.contributor.authorGuner, Savas
dc.contributor.authorAksakal, Bunyamin
dc.date.accessioned2024-09-18T20:04:30Z
dc.date.available2024-09-18T20:04:30Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: To demonstrate the biomechanical changes in rat bones occurred by surgical menopause and to search for correlation between biomechanical test results and bone mineral density (BMD) measurements. Methods: Thirty female Wistar-albino rats aged 6 months and weighed 250-300 g were randomized into ovariectomy, sham and control groups. After 6 months, rats were sacrificed and right femurs were extracted. BMD measurements and three point bending biomechanical tests were made in femurs. Results: The difference among the mean BMD measurements of three groups were found to be statistically significant (Pr>F value <0.0001). Mean elastic module, maximum elongation and femoral diameters were also found to be statistically significantly different (Pr>F value <0.05). Ovariectomised and sham-operated groups were significantly different in terms of elastic modulus. Ultimate force did not differ among the groups significantly. The difference between ultimate strain and maximum elongation of the ovariectomy and sham operated group was statistically significant. Conclusions: Bone quality was deteriorated and fragility was increased in rats 6 months after surgical menopause. Sole BMD measurement might not be reliable in evaluation of osteoporosis and fracture risk. Biomechanical quality of bone is more important than its mineral content in determining fragility.en_US
dc.identifier.doi10.3109/09513590.2013.854767
dc.identifier.endpage65en_US
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue1en_US
dc.identifier.pmid24195608en_US
dc.identifier.scopus2-s2.0-84890455002en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage62en_US
dc.identifier.urihttps://doi.org/10.3109/09513590.2013.854767
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8211
dc.identifier.volume30en_US
dc.identifier.wosWOS:000329952900013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofGynecological Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiomechanicsen_US
dc.subjectmenopauseen_US
dc.subjectosteoporosisen_US
dc.subjectovariectomyen_US
dc.subjectraten_US
dc.titleBiomechanical effects of menopause in ovariectomized rats' femursen_US
dc.typeArticleen_US

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