Thiol/disulfide homeostasis as a new oxidative stress marker in patients with Fabry disease

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dc.contributor.authorErdal, Huseyin
dc.contributor.authorTurgut, Faruk
dc.date.accessioned2024-09-18T20:19:59Z
dc.date.available2024-09-18T20:19:59Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis is the first study to show both dynamic thiol-disulfide balance and oxidative stress levels in patients with Fabry disease (FD). This prospective study consists of 30 FD patients and 30 healthy controls. Thiol and disulfide values of the study groups were evaluated using a new, cost-effective and fully automatic colorimetric method. A total of 60 subjects were included in the study. A statistically significant difference was found between the patient and control groups for native and total thiol levels (p < 0.001). In addition, disulfide levels were significantly higher in FD patients compared with the control group (p < 0.003). Native thiol levels showed significantly negative correlation with lysosomal globotriaosylceramide, total oxidant status (TOS), and oxidative stress index (OSI) levels. In addition, a positive correlation was found between disulfide/natural thiol and disulfide/total thiol ratios and TOS, OSI, and blood urea nitrogen. We found total antioxidant status levels were lower in the patient group compared to the control group, while TOS and OSI levels were higher and were statistically significant. This study highlights for the first time a novel, cost-effective and fully automated measurement of thiol-disulfide levels in patients with FD. Determination of thiol levels can make important contributions to understand the etiopathogenesis and follow-up of the disease in FD patients.en_US
dc.description.sponsorshipThe authors thank patients and controls for their voluntary support of the study.en_US
dc.description.sponsorshipThe authors thank patients and controls for their voluntary support of the study.en_US
dc.identifier.doi10.1177/10815589231191966
dc.identifier.endpage870en_US
dc.identifier.issn1081-5589
dc.identifier.issn1708-8267
dc.identifier.issue8en_US
dc.identifier.pmid37485970en_US
dc.identifier.scopus2-s2.0-85173658142en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage865en_US
dc.identifier.urihttps://doi.org/10.1177/10815589231191966
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9990
dc.identifier.volume71en_US
dc.identifier.wosWOS:001098990000010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal of Investigative Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFabry diseaseen_US
dc.subjectoxidative stressen_US
dc.subjectfree radicals thiol-disulfide homeostasisen_US
dc.subjectreactive oxygen speciesen_US
dc.titleThiol/disulfide homeostasis as a new oxidative stress marker in patients with Fabry diseaseen_US
dc.typeArticleen_US

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