Cases of organophosphate poisoning treated with high-dose of atropine in an intensive care unit and the novel treatment approaches

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dc.authoridkarakus, ali/0000-0003-1358-3201
dc.contributor.authorKarakus, Ali
dc.contributor.authorCelik, Muhammet Murat
dc.contributor.authorKarcioglu, Murat
dc.contributor.authorTuzcu, Kasim
dc.contributor.authorErden, Ersin Sukru
dc.contributor.authorZeren, Cem
dc.date.accessioned2024-09-18T20:52:57Z
dc.date.available2024-09-18T20:52:57Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOrganophosphate poisoning is a life-threatening condition, which is being responsible for the symptoms due to cholinergic effects. Clinical status and blood levels of cholinesterase are used its diagnosis. While atropine and pralidoxime (PAM) appear as essential medications, hemofiltration treatments and lipid solutions have been widely studied in recent years. In this study, the importance of high-dose atropine therapy and early intervention and novel treatment approaches are discussed. Records of a total of 25 patients treated for organophosphate poisoning in the intensive care unit (ICU) between April 2007 and December 2011 were evaluated retrospectively. Of the 25 patients, 14 (56%) were male and 11 (44%) were female with a mean age of 34.8 +/- 17.66 years (range: 14-77 years). The patients were most frequently admitted in June (n = 4) and July (n = 4) (16%). Of the 25 patients, 22 patients (88%) were poisoned by oral intake, two (8%) by inhalation, and one (4%) by dermal route. Of them, 20 patients (80%) took organophosphates intentionally for suicidal purposes, while five (20%) cases poisoned due to accidental exposure. The scores of Glasgow Coma Scale of nine patients (36%) were below 8 point upon admission to hospital. The highest dose of atropine given was 100 mg intravenously on admission and 100 mg/h/day during follow-up. The total dose given was 11.6 g/12 days. A total of 11 patients (44%) were on mechanical ventilation for a mean duration of 5.73 +/- 4.83 days. The mean duration of ICU stay was 6.52 +/- 4.80 days. Of all, 23 patients (92%) were discharged in good clinical condition and one patient (4%) was referred to another hospital. This study suggests that atropine can be administered until secretions disappear and intensive care should be exerted in follow-up of these patients. In addition, in case of necessity for high doses, sufficient amounts of atropine and PAM should be available in hospitals.en_US
dc.identifier.doi10.1177/0748233712462478
dc.identifier.endpage425en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue5en_US
dc.identifier.pmid23012340en_US
dc.identifier.scopus2-s2.0-84901762600en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage421en_US
dc.identifier.urihttps://doi.org/10.1177/0748233712462478
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11507
dc.identifier.volume30en_US
dc.identifier.wosWOS:000337579200004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOrganophosphate poisoningen_US
dc.subjectatropineen_US
dc.subjectalternative treatmentsen_US
dc.subjectintensive careen_US
dc.titleCases of organophosphate poisoning treated with high-dose of atropine in an intensive care unit and the novel treatment approachesen_US
dc.typeArticleen_US

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