Effects of montelukast on tendon healing in a murine model

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dc.authoridSaglam, Ibrahim/0000-0002-1706-4444
dc.authoridBOZDAG, ERGUN/0000-0001-7412-1129
dc.contributor.authorGideroglu, Kaan
dc.contributor.authorCakici, Husamettin
dc.contributor.authorHapa, Onur
dc.contributor.authorOzturan, Kutay E.
dc.contributor.authorBozdag, Ergun
dc.contributor.authorYilmaz, Fahri
dc.contributor.authorSaglam, Ibrahim
dc.date.accessioned2024-09-18T20:32:56Z
dc.date.available2024-09-18T20:32:56Z
dc.date.issued2017
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground Tendon injury induces a local inflammatory response characterized by the production of pro-inflammatory cytokines. The aim of this study is to investigate the effects of montelukast sodium on the healing of tendons through histological and biomechanical evaluations. Methods Forty-eight female Wistar albino rats were randomly assigned to an experimental group that received montelukast sodium (n = 24) and a control group (n = 24) that did not. Tendon injury was created in the Achilles tendon. The experimental group was injected intraperitoneally (IP) with 1 ml of 1 mg/kg montelukast sodium solution once a day prior to the surgery and during the experimental research. The control group was injected with saline solution. Two weeks later, eight rats in each group underwent a histological evaluation. In the fourth week, eight rats underwent a histological evaluation and the other eight rats went through a biomechanical evaluation. Results Based on the histological evaluation in the second week, it was observed that the severity of the inflammation was less in the experimental group that received montelukast sodium (p < 0.05). In terms of the formation of collagen, no significant difference was observed between the groups in the second and fourth weeks. Tendon breaking loads were 33.2 +/- 10.95 and 38.8 +/- 10.90 N for the montelukast group and the control group, respectively. However, the difference between the groups was found to be statistically insignificant (p > 0.05). Conclusions There was no negative effect on the healing of tendons due to injection of montelukast sodium. In addition, observing less inflammation in the experimental group in the earlier phase suggests that montelukast sodium may help in preventing tendon adhesion after reconstructive treatment.en_US
dc.identifier.doi10.1007/s00238-017-1283-1
dc.identifier.endpage176en_US
dc.identifier.issn0930-343X
dc.identifier.issn1435-0130
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85014682422en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage171en_US
dc.identifier.urihttps://doi.org/10.1007/s00238-017-1283-1
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11224
dc.identifier.volume40en_US
dc.identifier.wosWOS:000401979600001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal of Plastic Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMontelukasten_US
dc.subjectTendon healingen_US
dc.subjectExperimental studyen_US
dc.subjectInflammationen_US
dc.titleEffects of montelukast on tendon healing in a murine modelen_US
dc.typeArticleen_US

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