Association of UCMA levels in serum and synovial fluid with severity of knee osteoarthritis

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dc.authoridozcan, oguzhan/0000-0001-7486-503X
dc.authoridTerzi, Menderes Yusuf/0000-0001-8478-0451
dc.authoridOkuyan, Hamza Malik/0000-0001-7616-3330
dc.contributor.authorOkuyan, Hamza Malik
dc.contributor.authorTerzi, Menderes Yusuf
dc.contributor.authorOzcan, Oguzhan
dc.contributor.authorKalacı, Aydıner
dc.date.accessioned2024-09-18T20:52:58Z
dc.date.available2024-09-18T20:52:58Z
dc.date.issued2019
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim Osteoarthritis (OA) is one of the most common joint diseases causing physical disability in the aged population. OA pathogenesis is not fully known and yet there are no effective therapeutic options against OA. Upper Zone of Growth Plate and Cartilage Matrix Associated (UCMA) is a member of vitamin K-dependent protein family, and is involved in inflammation, cardiovascular diseases, cancer, and OA. In the present study, our aim was to detect serum and synovial fluid (SF) levels of UCMA and to analyze their correlation with radiographic findings and symptomatic severity in OA patients as well as the correlation between oxidative stress levels and SF UCMA levels. Methods Forty OA patients with cartilage degeneration and 20 patients with other knee joint disorders (non-OA control) were included in the present study. We used the Kellgren-Lawrence (KL) classification and Western Ontario McMaster University Osteoarthritis Index (WOMAC) scores to assess radiographic grading and symptomatic severity of OA, respectively. UCMA levels were measured in SF and serum. And also oxidative stress markers were analyzed in SF. Results SF UCMA levels of OA patients were higher compared to those of the non-OA control group and were positively correlated with radiographic finding and symptomatic severity of OA. However, there was no significant correlation between oxidative markers of SF and the KL grade, WOMAC scores, and SF UCMA levels in OA patients. Conclusion There is a close connection between UCMA SF levels and symptomatic and radiographic severities of knee OA. Therefore, UCMA can be a promising biomarker in the diagnosis and/or prognosis of OA disease.en_US
dc.description.sponsorshipScientific Research Project Fund of Hatay Mustafa Kemal University [18.M.016]en_US
dc.description.sponsorshipThis work is supported by the Scientific Research Project Fund of Hatay Mustafa Kemal University under the project number 18.M.016.en_US
dc.identifier.doi10.1111/1756-185X.13682
dc.identifier.endpage1890en_US
dc.identifier.issn1756-1841
dc.identifier.issn1756-185X
dc.identifier.issue10en_US
dc.identifier.pmid31424176en_US
dc.identifier.scopus2-s2.0-85070807555en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1884en_US
dc.identifier.urihttps://doi.org/10.1111/1756-185X.13682
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11519
dc.identifier.volume22en_US
dc.identifier.wosWOS:000482114500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal of Rheumatic Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectosteoarthritisen_US
dc.subjectoxidative stress indexen_US
dc.subjectserumen_US
dc.subjectsynovial fluiden_US
dc.subjectupper zone of growth plate and cartilage matrix associateden_US
dc.titleAssociation of UCMA levels in serum and synovial fluid with severity of knee osteoarthritisen_US
dc.typeArticleen_US

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