Nasobiliary Drainage for Benign Recurrent Intrahepatic Cholestasis in Patients Refractory to Standard Therapy

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dc.authoridSerin, Ender/0000-0002-0138-6107
dc.contributor.authorYakar, Tolga
dc.contributor.authorDemir, Mehmet
dc.contributor.authorGokturk, Huseyin S.
dc.contributor.authorKanat, Ayse G. Unler
dc.contributor.authorParlakgumus, Alper
dc.contributor.authorOzer, Birol
dc.contributor.authorSerin, Ender
dc.date.accessioned2024-09-18T21:07:58Z
dc.date.available2024-09-18T21:07:58Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: Benign recurrent intrahepatic cholestasis (BRIC) is characterized by episodic cholestasis and pruritus without anatomical obstruction. The aim of this study was to evaluate the safety and efficacy of nasobiliary drainage (NBD) in patients with BRIC refractory to medical therapy and to determine whether the use of NBD prolongs the episode duration. Methods: This was a multicenter retrospective study consisting of 33 patients suffering from BRIC. All patients were administrated medical treatment and 16 patients who were refractory to standard medical therapies improved on treatment with temporary endoscopic NBD. Duration of treatment response and associated complications were analyzed. Results: Sixteen patients (43% females) underwent 25 NBD procedures. The median duration of NBD was 17 days. There were significant improvements in total and direct bilirubin and alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma-glutamyl transpeptidase on the 3rd day of NBD. Longer clinical remission was monitored in the NBD group. Post-endoscopic retrograde cholangiopancreatography pancreatitis was observed in one of 16 cases. Conclusion: NBD effectively eliminates BRIC in all patients and improves biomarkers of cholestasis. It can be suggested that patients with attacks of BRIC can be treated with temporary endoscopic NBD; however, the results of this study should be confirmed by prospective studies in the future.en_US
dc.identifier.endpageS172en_US
dc.identifier.issn0147-958X
dc.identifier.issn1488-2353
dc.identifier.issue6en_US
dc.identifier.startpageS164en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14055
dc.identifier.volume39en_US
dc.identifier.wosWOS:000389725000032en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherCanadian Soc Clinical Investigationen_US
dc.relation.ispartofClinical and Investigative Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPost-Ercp Pancreatitisen_US
dc.subjectTerm-Follow-Upen_US
dc.subjectRectal Indomethacinen_US
dc.subjectRemissionen_US
dc.subjectPruritusen_US
dc.subjectTrialen_US
dc.titleNasobiliary Drainage for Benign Recurrent Intrahepatic Cholestasis in Patients Refractory to Standard Therapyen_US
dc.typeArticleen_US

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