Peripheral nervous system involvement in patients with sickle cell disease

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dc.authoridDUMAN, Taskin/0000-0002-6552-4193
dc.contributor.authorOkuyucu, E. E.
dc.contributor.authorTurhanoglu, A.
dc.contributor.authorDuman, T.
dc.contributor.authorKaya, H.
dc.contributor.authorMelek, I. M.
dc.contributor.authorYilmazer, S.
dc.date.accessioned2024-09-18T20:52:43Z
dc.date.available2024-09-18T20:52:43Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPeripheral nervous system involvement is rare in sickle cell disease (SCD). The aim of this study is to determine the peripheral nerve involvement electrophysiologically in SCD patients without clinically evident neurological signs, symptoms and to determine the relationship between the frequency of sickle cell crisis and peripheral neuropathy. Fifty-one patients with SCD and fifty-one healthy controls were enrolled to the study. Conventional electrophysiological studies of peripheral nerves were performed to all subjects. The data about the frequency of sickle cell crisis were obtained. Peripheral nervous sytem involvement was detected in ten (19.6%) patients. Five (9.8%) patients had sensorimotor axonal neuropathy, two (3.9%) sensory axonal neuropathy, one (2%) patient had ulnar sensory neuropathy and two (3.9%) had median sensory neuropathy. Sural nerve sensorial action potential was unobtainable in eight (15.7%) patients and prolonged F latencies were observed in three (5.9%). The frequency of neuropathy was higher in SCD patients when compared with the controls. The frequency of sickle cell crisis was not significantly correlated with peripheral neuropathy. Subclinical peripheral nerve involvement may be seen in SCD patients. Electrophysiological examinations are recommended in routine examination to diagnose early neuropathy in SCD patients without neurologic symptoms.en_US
dc.identifier.doi10.1111/j.1468-1331.2009.02592.x
dc.identifier.endpage818en_US
dc.identifier.issn1351-5101
dc.identifier.issue7en_US
dc.identifier.pmid19473371en_US
dc.identifier.scopus2-s2.0-66749114839en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage814en_US
dc.identifier.urihttps://doi.org/10.1111/j.1468-1331.2009.02592.x
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11343
dc.identifier.volume16en_US
dc.identifier.wosWOS:000266637000010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwell Publishing, Incen_US
dc.relation.ispartofEuropean Journal of Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectneuropathyen_US
dc.subjectsickle cell diseaseen_US
dc.titlePeripheral nervous system involvement in patients with sickle cell diseaseen_US
dc.typeArticleen_US

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