Spectrophotometric determination and stability studies of sulfamethoxazole and trimethoprim in oral suspension by classical least square calibration method

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dc.authorscopusid6505975951
dc.authorscopusid55896957400
dc.contributor.authorHişmio?ullari, Şahver Ege
dc.contributor.authorYarsan, Ender
dc.date.accessioned2024-09-19T15:45:29Z
dc.date.available2024-09-19T15:45:29Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractQuantitative determination and stability test of sulfamethoxazole and trimethoprim in oral suspension were carried out by spectrophometric classical least square calibration method. Stability test of the related veterinary drugs was performed by using the following conditions: Room temperature, refrigerator and etuve (37 0C) for each 3 month during 12 months. For the spectrophotometric analysis, the standard series of sulfamethoxazole and trimethoprim was prepared in the concentration range of 2.0-11.0 ?g/mL and 3.0-18.0 ?g/mL respectively. The absorbances of standard series were measured at three-wavelength set (237, 257 and 288 nm). A classical least square calibration was obtained by using the absorptivities at three-wavelength set. The validity of the spectral method was done by analyzing the synthetic binary mixtures. Afterwards the method was successfully applied to simultaneous analysis and stability test of the commercial veterinary formulation containing sulfamethoxazole and trimethoprim.en_US
dc.identifier.endpage104en_US
dc.identifier.issn1300-0608
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-78349233540en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage95en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14721
dc.identifier.volume29en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherHacettepe University, Faculty of Pharmacyen_US
dc.relation.ispartofHacettepe University Journal of the Faculty of Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChemometryen_US
dc.subjectSimultaneous determinationen_US
dc.subjectSpectral classical least squareen_US
dc.subjectStability testen_US
dc.subjectSulfamethoxazoleen_US
dc.subjectTrimethoprimen_US
dc.titleSpectrophotometric determination and stability studies of sulfamethoxazole and trimethoprim in oral suspension by classical least square calibration methoden_US
dc.title.alternativeOral süspansiyondaki sülfametoksazol ve trimetoprimin klasik küçük kare kalibrasyon metodu ile spektrofotometrik tayinleri ve Stabilite Çalışmalariaıen_US
dc.typeArticleen_US

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