Association between periodontal inflamed surface area and serum acute phase biomarkers in patients with sickle cell anemia

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dc.contributor.authorSari, Aysegul
dc.contributor.authorIlhan, Gul
dc.contributor.authorAkcali, Aliye
dc.date.accessioned2024-09-18T20:13:30Z
dc.date.available2024-09-18T20:13:30Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives: The aim of the present cross-sectional study was to investigate the association between periodontal inflamed surface area (PISA) and serum inflammatory biomarkers in patients with sickle cell anemia. Design: Patients with sickle cell anemia (n = 80) and systemically healthy individuals (n = 80) were enrolled in the study. Crisis episodes were recorded and blood samples were collected from patients with sickle cell anemia. Clinical periodontal parameters and PISA values were calculated from all patients. Ferritin and high sensitivity C-reactive protein (hs-CRP) levels were analyzed biochemically. Results: In sickle cell anemia group, presence of periodontitis (p < 0.001) was more frequent than periodontal health (p < 0.001). All clinical periodontal recordings and PISA values were higher in the sickle cell anemia group compared to controls (p < 0.001). Patients with PISA > 776 mm(2) had 6.06-fold greater chances of having hs-CRP levels above 10 mg/L (OR = 6.06; 95 % CI: 1.9-19.26) and had 31.41-fold greater chances of having ferritin levels above 1000 ng/L (OR = 31.41; 95 % CI: 6.62-149.16). Also, they had 3.27-fold greater risk of having crisis frequency above three times per year (OR = 3.27; 95 % CI: 1.05-10.23) after adjusting for confounders. Conclusion: In patients with sickle cell anemia, positive association was evident between PISA values and serum acute phase biomarkers levels as well as the frequency of acute painful crisis. Patients with increased inflammatory burden may have a higher likelihood of developing periodontitis in the presence of sickle cell anemia. PISA value could be a candidate disease activity indicator in patients with an underlying hematological condition.en_US
dc.identifier.doi10.1016/j.archoralbio.2022.105543
dc.identifier.issn0003-9969
dc.identifier.issn1879-1506
dc.identifier.pmid36155345en_US
dc.identifier.scopus2-s2.0-85138562310en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.archoralbio.2022.105543
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9231
dc.identifier.volume143en_US
dc.identifier.wosWOS:000864542100002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofArchives of Oral Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectC-reactive proteinen_US
dc.subjectPeriodontal diseaseen_US
dc.subjectPeriodontal inflamed surface areaen_US
dc.subjectPeriodontitisen_US
dc.subjectSickle cell anemiaen_US
dc.titleAssociation between periodontal inflamed surface area and serum acute phase biomarkers in patients with sickle cell anemiaen_US
dc.typeArticleen_US

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