The scintigraphic, biodistribution and histopathological evaluation of the effect of experimental 131I administration on the gastrointestinal system and the demonstration of the Na+/I- symporter by immunohistochemistry in rats

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dc.authoridYilmaz, Rahsan/0000-0002-0944-2230
dc.contributor.authorYilmaz, Rahsan
dc.contributor.authorYumusak, Nihat
dc.contributor.authorSadic, Murat
dc.contributor.authorAtilgan, Hasan I.
dc.contributor.authorKorkmaz, Meliha
dc.contributor.authorBozkaya, Faruk
dc.date.accessioned2024-09-18T20:04:27Z
dc.date.available2024-09-18T20:04:27Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectiveThe aim of this study was to investigate histopathological changes and biodistribution of iodine-131 (I-131) in the gastrointestinal system (GIS) and also Na+/I- Symporter (NIS) presence by immunohistochemically in the experimental treatment of rats with radioactive iodine (RAI).Materials and methodsRats were divided into experimental and control groups as random early group 2 (24h), intermediate group 3 (3 weeks), and late period group 4 (3 months). Experimental groups were administered 100MBq (approximate to 3mCi, 12mCi/kg) by orogastric route with orogastric tube. Scintigraphic iodine screening images were obtained 24h, 3 weeks, and 3 months after RAI, and GIS tissues were removed, and immunohistochemical methods were used to demonstrate NIS with RAI biodistribution and histopathology.ResultsAccording to the results of scintigraphy, the most prominent activity involvement was observed in the thyroid gland at group 2, and significant activity was observed in the stomach. In the group 3 and group 4 images, owing to the physiological and biological half-life of the iodine and low resolution of the gamma camera, no secondary focal activation was observed. The highest RAI biodistribution value in all groups was in the stomach, ileum and oesophagus. In the immunohistochemical examination of NIS, the highest staining sequence was observed in all groups respectively in the stomach, oesophagus, tongue, colon, saliva, duodenum, rectum, ileum and jejunum. The increase of NIS immunohistochemically stained more intensely was observed in the RAI-administered groups.ConclusionThe amount of NIS is important for the absorption of RAI after administration.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [214O704]en_US
dc.description.sponsorshipThis study was supported by the Scientific and Technological Research Council of Turkey (No: 214O704).en_US
dc.identifier.doi10.1097/MNM.0000000000000841
dc.identifier.endpage520en_US
dc.identifier.issn0143-3636
dc.identifier.issn1473-5628
dc.identifier.issue6en_US
dc.identifier.pmid29652748en_US
dc.identifier.scopus2-s2.0-85047853206en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage511en_US
dc.identifier.urihttps://doi.org/10.1097/MNM.0000000000000841
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8181
dc.identifier.volume39en_US
dc.identifier.wosWOS:000433097200007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofNuclear Medicine Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbiodistributionen_US
dc.subjectgastrointestinal systemen_US
dc.subjecthistopathologyen_US
dc.subjectI-131en_US
dc.subjectimmunohistochemistryen_US
dc.subjectNa+en_US
dc.subjectI- Symporteren_US
dc.subjectraten_US
dc.subjectscintigraphyen_US
dc.titleThe scintigraphic, biodistribution and histopathological evaluation of the effect of experimental 131I administration on the gastrointestinal system and the demonstration of the Na+/I- symporter by immunohistochemistry in ratsen_US
dc.typeArticleen_US

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