Inhibition of neuronal nitric oxide synthase prevents iron-induced cerebellar Purkinje cell loss in the rat

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dc.authoridSefil, Fatih/0000-0001-5534-7448
dc.authoridBOSTANCI, Mehmet Omer/0000-0002-2887-1073
dc.contributor.authorGulturk, Sefa
dc.contributor.authorKozan, Ramazan
dc.contributor.authorBostanci, M. Omer
dc.contributor.authorSefil, Fatih
dc.contributor.authorBagirici, Faruk
dc.date.accessioned2024-09-18T20:28:10Z
dc.date.available2024-09-18T20:28:10Z
dc.date.issued2008
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIron plays an important role in maintaining normal. brain function. However, in many neurodegenerative diseases abnormal iron accumulation in specific brain regions has been consistently reported. In this study, we investigated the neurotoxic effect of the intracerebroventricularly injected iron on the cerebellar Purkinje cells in the rat and the role of nitric oxide (NO) in this process. The role of NO in rats administered iron (FeCl(3)6H(2)O) was examined with the use of a donor of NO, L-arginine (L-Arg), and a central selective inhibitor of NO synthase, 7-nitroindazole (7-NI). For this reason, rats were divided into 5 groups: control, iron-injected, iron plus L-Arg, iron plus 7-NI, and iron plus L-Arg plus 7-NI. Means (value standard deviation) of the total numbers of Purkinje cells in the cerebellum were estimated as 337 +/- 23, 209 +/- 16, 167 +/- 19, 305 26, and 265 +/- 14 thousands in the control, iron, iron plus L-Arg, iron plus 7-NI, and iron plus L-Arg plus 7-NI groups, respectively. Iron treatment alone and the combination of iron and L-Arg caused a significant reduction in the total number of cerebellar Purkinje cells. Therefore, L-Arg increased the Purkinje cell loss induced by treatment with iron. These data show that inhibition of the neuronal NOS by 7-NI can prevent some of the deleterious effects of iron on cerebellar Purkinje cells. Presence of L-arginine decreased the neuroprotective effect of 7-NI.en_US
dc.identifier.endpage31en_US
dc.identifier.issn0065-1400
dc.identifier.issn1689-0035
dc.identifier.issue1en_US
dc.identifier.pmid18389011en_US
dc.identifier.scopus2-s2.0-41749105607en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage26en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10769
dc.identifier.volume68en_US
dc.identifier.wosWOS:000255347300003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNencki Inst Experimental Biologyen_US
dc.relation.ispartofActa Neurobiologiae Experimentalisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectironen_US
dc.subjectneurotoxicityen_US
dc.subjectPurkinje cellen_US
dc.subjectnitric oxideen_US
dc.subjectstereologyen_US
dc.titleInhibition of neuronal nitric oxide synthase prevents iron-induced cerebellar Purkinje cell loss in the raten_US
dc.typeArticleen_US

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