Hepatoprotective Activity of Linalool in Rats Against Liver Injury Induced by Carbon Tetrachloride

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dc.authoridYipel, Mustafa/0000-0002-6390-9313
dc.authoridGUVENC, MEHMET/0000-0002-9716-0697
dc.authoridTekeli, Ibrahim Ozan/0000-0002-6845-2279
dc.authoridKaya, Durmus Alpaslan/0000-0003-3544-9214
dc.authoridAltinok-Yipel, Fulya/0000-0001-8577-2031
dc.contributor.authorAltinok-Yipel, Fulya
dc.contributor.authorTekeli, Ibrahim Ozan
dc.contributor.authorOzsoy, Sule Yurdagul
dc.contributor.authorGuvenc, Mehmet
dc.contributor.authorKaya, Alpaslan
dc.contributor.authorYipel, Mustafa
dc.date.accessioned2024-09-18T20:06:31Z
dc.date.available2024-09-18T20:06:31Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis study aimed to investigate and compare hepatoprotective activity of Coriandrum sativum (Cs) and it is major component linalool (Ln) against experimentally induced hepatotoxicity in rats. Essential oil of Cs was isolated by hydrodistillation method and chemical composition was determined by GS-MS analysis. 42 male Wistar Albino rats were divited into 7 groups each containing 6. The experimental groups were designed as: Normal control group, 1 ml/kg CCl4 administirated group, 25 mg/kg Silymarin and CCl4 administirated group, 100 and 200 mg/kg Cs and CCl4 administirated groups, 100 and 200 mg/kg Ln and CCl4 administered groups. The protective activities were determined according to the results of liver biomarkers (AST, ALT, ALP), antioxidant parameters (GSH, GPx, CAT), lipid peroxidation (MDA) and histopathological examination. Linalool percentage of Cs was 81.6%. The groups treated with linalool (100 and 200 mg/kg) (p < 0.01) and coriander (200 mg/kg) (p < 0.05) had significantly reduced AST (262-375) and ALT (101-290) levels (U/L) compared to the CCl4 (600-622) group. The levels (nmol/g protein) of MDA (11-12) were significantly lower (p < 0.01), the levels of GSH (11-12) and the activities of CAT (23-24) were significantly higher (p < 0.01) in linalool groups (100 and 200 mg/kg) compared to the CCl4 (18-5-10 respectively) group. These results were also supported by histopathological findings and indicate that Cs and Ln shows hepatoprotective activity against liver damage. In this regard, evaluation of activities of major components are needed to compare to medicinal plants in experimental diseases models.en_US
dc.identifier.doi10.1024/0300-9831/a000581
dc.identifier.endpage308en_US
dc.identifier.issn0300-9831
dc.identifier.issn1664-2821
dc.identifier.issue3-4en_US
dc.identifier.pmid30932786en_US
dc.identifier.scopus2-s2.0-85086346224en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage302en_US
dc.identifier.urihttps://doi.org/10.1024/0300-9831/a000581
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8558
dc.identifier.volume90en_US
dc.identifier.wosWOS:000540719600015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerlag Hans Huberen_US
dc.relation.ispartofInternational Journal For Vitamin and Nutrition Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarbon tetrachlorideen_US
dc.subjectCoriandrum sativumen_US
dc.subjecthepatoprotectiveen_US
dc.subjectlinaloolen_US
dc.titleHepatoprotective Activity of Linalool in Rats Against Liver Injury Induced by Carbon Tetrachlorideen_US
dc.typeArticleen_US

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