Frequency of Familial Mediterranean Fever Gene Mutation in Patients Presenting With Joint Pain and Diagnosed With Acute Rheumatic Fever

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dc.contributor.authorGullu, Ufuk U.
dc.contributor.authorBalaban, Ismail
dc.contributor.authorKara, Soner Sertan
dc.contributor.authorYarali, Oguzhan
dc.contributor.authorTurkyilmaz, Ayberk
dc.contributor.authorIpek, Sevcan
dc.contributor.authorGullu, Seyma D.
dc.date.accessioned2024-09-18T21:01:36Z
dc.date.available2024-09-18T21:01:36Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIntroduction Acute rheumatic fever (ARF) is a non-suppurative systemic inflammatory disease that manifests 1-5 weeks following a Group A beta-hemolytic streptococcal infection. On the other hand, familial Mediterranean fever (FMF) is a hereditary autoinflammatory disease characterized as an autosomal recessive disease, with affected individuals having pathogenic mutations in the Mediterranean fever gene (MEFV) gene located on the short arm of chromosome 16. FMF and ARF have overlapping symptoms and signs, and both disorders are common in Turkey. In ARF, the target organ is the heart, while in FMF, the target organ is the kidney; both organs can benefit from prophylactic measures. Our study aims to determine the frequency of the FMF gene mutation in patients with ARF in Turkey and detect any overlapping conditions. Method Patients who were diagnosed with a first-attack ARF between May 2015 and May 2018 were retrospectively screened. Patients who underwent MEFV gene analysis considering FMF in the differential diagnosis were included in the study. Results In this study, no statistical difference was found between the presence of MEFV gene mutations, carditis, high anti-streptolysin-O antibody (ASO) levels, and the groups with monoarthritis, polyarthritis, and polyarthralgia (p >0.05). Conclusions In conclusion, patients with ARF should be evaluated for FMF to avoid irreversible complications.en_US
dc.identifier.doi10.7759/cureus.43001
dc.identifier.issn2168-8184
dc.identifier.issue8en_US
dc.identifier.pmid37671203en_US
dc.identifier.urihttps://doi.org/10.7759/cureus.43001
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12870
dc.identifier.volume15en_US
dc.identifier.wosWOS:001053911400008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofCureus Journal of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectyalcinkaya-ozen criteriaen_US
dc.subjectmefv gene mutationen_US
dc.subjectfamilial mediterranean feveren_US
dc.subjectjoint painen_US
dc.subjectacute rheumatic feveren_US
dc.titleFrequency of Familial Mediterranean Fever Gene Mutation in Patients Presenting With Joint Pain and Diagnosed With Acute Rheumatic Feveren_US
dc.typeArticleen_US

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