Protective role of the dried white mulberry extract on the reproductive damage and fertility in rats treated with carmustine

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dc.authoridCorum, Orhan/0000-0003-3168-2510
dc.authoridYeni, Deniz/0000-0002-9105-5677
dc.authoridIPEK, VOLKAN/0000-0001-5874-7797
dc.authoridINANC, MUHAMMED ENES/0000-0001-6954-6309
dc.contributor.authorInanc, Muhammed Enes
dc.contributor.authorGungor, Sukru
dc.contributor.authorYeni, Deniz
dc.contributor.authorAvdatek, Fatih
dc.contributor.authorIpek, Volkan
dc.contributor.authorTurkmen, Ruhi
dc.contributor.authorCorum, Orhan
dc.date.accessioned2024-09-18T20:16:34Z
dc.date.available2024-09-18T20:16:34Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe present study investigated the protective effect of dried white Mulberry extract (DWME) against carmustine (Crm) induced biochemical alterations and spermatological, histopathological, and fertility damage in Wistar albino rats. Male rats were divided into four groups (control, Crm, Crm + DWME, and DWME group). It was found that Crm decreased the motility. Crm decreased the concentration (not different from control group) compared to DWME groups. Total blood MDA levels were reduced during the recovery period. Also, the recovery period reduced the MDA levels in the Crm group/testicular tissue. The GSH levels in the Crm + DWME group were the highest among all groups in the testicular tissue/experiment period. In the immunohistochemical evaluation of the testicular tissue, a high level of caspase 3 was observed in the cells that underwent meiosis in the Crm group. The most pronounced DNA damage was also detected in the Crm group. The Crm + DWME group showed the highest number of offspring born during recovery period. In conclusion, dried white mulberry extract protects against the spermatological damages caused by carmustine. Moreover, recovery period played a positive effect on spermatological parameters and fertility.en_US
dc.description.sponsorshipTurkish Scientific and Technological Research Council (TUBITAK) [218O162]en_US
dc.description.sponsorshipThis study financed under the Project supported by the Turkish Scientific and Technological Research Council (TUBITAK) (Project No: 218O162) . The authors thanks Mehmet Sukru Gulay, Research and Innovation Support for Higher Impact (RISHI) and Sci-Edit Publication Services for proofreading and data control the article and Gaffari Turk and Okkes Yilmaz for total phenol and flavonoid levels analysis.en_US
dc.identifier.doi10.1016/j.fct.2022.112979
dc.identifier.issn0278-6915
dc.identifier.issn1873-6351
dc.identifier.pmid35398183en_US
dc.identifier.scopus2-s2.0-85128203502en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.fct.2022.112979
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9590
dc.identifier.volume163en_US
dc.identifier.wosWOS:000829867900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofFood and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDried white mulberry fruit extract (DWME)en_US
dc.subjectRaten_US
dc.subjectCarmustineen_US
dc.subjectChemotherapyen_US
dc.subjectFertilityen_US
dc.subjectSpermatological parametersen_US
dc.titleProtective role of the dried white mulberry extract on the reproductive damage and fertility in rats treated with carmustineen_US
dc.typeArticleen_US

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