The protective effect of N-acetylcysteine against cyclosporine A-induced hepatotoxicity in rats

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dc.contributor.authorKaya, Hasan
dc.contributor.authorKoc, Ahmet
dc.contributor.authorSogut, Sadik
dc.contributor.authorDuru, Mehmet
dc.contributor.authorYilmaz, H. Ramazan
dc.contributor.authorUz, Efkan
dc.contributor.authorDurgut, Ramazan
dc.date.accessioned2024-09-18T20:13:43Z
dc.date.available2024-09-18T20:13:43Z
dc.date.issued2008
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe immunosuppressive agent cyclosporine A (CsA) has been reported to exert measurable hepatotoxic effects. One of the causes leading to hepatotoxicity is thought to be reactive oxygen radical formation. The aim of this study was to investigate the effects of N-acetylcysteine (NAC) treatment on CsA-induced hepatic damage by both analysing superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), aspartate aminotransferase (AST) and alanine transaminase (ALT) activities with malondialdehyde (MDA) and nitric oxide (NO) levels, and using an histological approach. CsA administration produced a decrease in hepatic SOD activity, and co-administration of NAC with CsA resulted in an increase in SOD activity. MDA and NO levels increased in the CsA group and NAC treatment prevented those increases. A significant elevation in serum AST and ALT activities was observed in the CsA group, and when NAC and CsA were co-administered, the activities of AST and ALT were close to the control levels. CsA treatment caused evident morphological alterations. Control rats showed no abnormality in the cytoarchitecture of the hepatic parenchyma. The co-administration of NAC with CsA showed no signs of alteration and the morphological pattern was almost similar to the control group. In conclusion, CsA induced liver injury and NAC treatment prevented the toxic side effects induced by CsA administration through the antioxidant and radical scavenging effects of NAC. Copyright (C) 2007 John Wiley & Sons, Ltd.en_US
dc.identifier.doi10.1002/jat.1245
dc.identifier.endpage20en_US
dc.identifier.issn0260-437X
dc.identifier.issue1en_US
dc.identifier.pmid17461432en_US
dc.identifier.scopus2-s2.0-38349057749en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage15en_US
dc.identifier.urihttps://doi.org/10.1002/jat.1245
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9336
dc.identifier.volume28en_US
dc.identifier.wosWOS:000252511600003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJohn Wiley & Sons Ltden_US
dc.relation.ispartofJournal of Applied Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcyclosporine Aen_US
dc.subjectN-acetylcysteineen_US
dc.subjecthepatotoxicityen_US
dc.subjectoxidanten_US
dc.subjectantioxidanten_US
dc.titleThe protective effect of N-acetylcysteine against cyclosporine A-induced hepatotoxicity in ratsen_US
dc.typeArticleen_US

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