Lipid nanocarriers based on natural oils with high activity against oxygen free radicals and tumor cell proliferation

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dc.authoridOprea, Ovidiu/0000-0002-8145-1094
dc.authoridMihaila, Mirela Antonela/0000-0001-8302-8823
dc.authoridNicoleta, Badea/0000-0002-9450-8387
dc.authoridKaya, Durmus Alpaslan/0000-0003-3544-9214
dc.contributor.authorLacatusu, I.
dc.contributor.authorBadea, N.
dc.contributor.authorBadea, G.
dc.contributor.authorOprea, O.
dc.contributor.authorMihaila, M. A.
dc.contributor.authorKaya, D. A.
dc.contributor.authorStan, R.
dc.date.accessioned2024-09-18T20:25:15Z
dc.date.available2024-09-18T20:25:15Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe development of nano-dosage forms of phytochemicals represents a significant progress of the scientific approach in the biomedical research. The aim of this study was to assess the effectiveness of lipid nanocarriers based on natural oils (grape seed oil, fish oil and laurel leaf oil) in counteracting free radicals and combating certain tumor cells. No drug was encapsulated in the nanocarriers. The cytotoxic effect exerted by bioactive nanocarriers against two tumor cells, MDA-MB 231 and HeLa cell lines, and two normal cells, L929 and B16 cell lines, was measured using the MTT assay, while oxidative damage was assessed by measuring the total antioxidant activity using chemiluminescence analysis. The best performance was obtained for nanocarriers based on an association of grape seed and laurel leaf oils, with a capacity to scavenge about 98% oxygen free radicals. A dose of nanocarriers of 5 mg.mL(-1) has led to a drastic decrease in tumor cell proliferation even in the absence of an antitumor drug (e.g. about 50% viability for MDA-MB 231 cell line and 60% viability for HeLa cell line). A comparative survival profile of normal and tumor cells, which were exposed to an effective dose of 2.5 mg.mL(-1) lipid nanocarriers, has revealed a death rate of 20% for normal B16 cells and of 40% death rate for MDA-MB 231 and HeLa tumor cells. The results in this study imply that lipid nanocarriers based on grape seed oil in association with laurel leaf oil could be a candidate to reduce the delivery system toxicity and may significantly improve the therapeutic efficacy of antitumor drugs in clinical applications. (C) 2015 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipNational Education Ministry, CNCS - UEFISCDI [PCE_PN-II-ID-PCE-2012-4-0111]en_US
dc.description.sponsorshipThe work was supported by a grant of the National Education Ministry, CNCS - UEFISCDI, project number PCE_PN-II-ID-PCE-2012-4-0111.en_US
dc.identifier.doi10.1016/j.msec.2015.06.019
dc.identifier.endpage94en_US
dc.identifier.issn0928-4931
dc.identifier.issn1873-0191
dc.identifier.pmid26249569en_US
dc.identifier.scopus2-s2.0-84935876142en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage88en_US
dc.identifier.urihttps://doi.org/10.1016/j.msec.2015.06.019
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10190
dc.identifier.volume56en_US
dc.identifier.wosWOS:000359873900011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofMaterials Science & Engineering C-Materials For Biological Applicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFunctional nanocarriersen_US
dc.subjectLaurel leaf oilen_US
dc.subjectGrape seed oilen_US
dc.subjectAntioxidant activityen_US
dc.subjectTumor cell declineen_US
dc.titleLipid nanocarriers based on natural oils with high activity against oxygen free radicals and tumor cell proliferationen_US
dc.typeArticleen_US

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