Development and Investigation of an Innovative 3D Biohybrid Based on Collagen and Silk Sericin Enriched with Flavonoids for Potential Wound Healing Applications

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dc.authoridPopa, Andreea Daniela/0000-0001-7185-9945
dc.authoridDinescu, Sorina/0000-0001-7196-1712
dc.authoridAlbu, Madalina Georgiana/0000-0001-9960-2244
dc.contributor.authorSleiman, Lea
dc.contributor.authorLazar (Popa), Andreea-Daniela
dc.contributor.authorAlbu-Kaya, Madalina
dc.contributor.authorMarin, Minodora Maria
dc.contributor.authorKaya, Durmus Alpaslan
dc.contributor.authorVasile, Otilia-Ruxandra
dc.contributor.authorDinescu, Sorina
dc.date.accessioned2024-09-18T21:01:36Z
dc.date.available2024-09-18T21:01:36Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractSkin tissue injuries necessitate particular care due to associated complex healing mechanisms. Current investigations in the domain of tissue engineering and regenerative medicine are focused on obtaining novel scaffolds adapted as potential delivery systems to restore lost tissue functions and properties. In this study, we describe the fabrication and evaluation of a novel 3D scaffold structure based on collagen and silk sericin (CollSS) enriched with microcapsules containing natural compounds, curcumin (C), and/or quercetin (Q). These 3D composites were characterized by FT-IR spectroscopy, water uptake, in vitro collagenase degradation, and SEM microscopy. Furthermore, they were biologically evaluated in terms of biocompatibility, cell adhesion, anti-inflammatory, and antioxidant properties. All tested materials indicated an overall suitable biocompatibility, with the best results obtained for the one containing both flavonoids. This study suggests the cumulative beneficial effect of C and Q, encapsulated in the same composite, as a potential non-invasive therapeutic strategy for skin tissue regeneration in patients suffering from chronic wounds.en_US
dc.description.sponsorshipMinistry of Research, Innovation and Digitalization, CCCDI-UEFISCDI within PNCDI III [PN-III-P2-2.1-PED-2021-2917 (622PED/2022)]; The project INOVEX: Susttinerea Dezvoltarii unor noi competente si instrumente inovative pentru excelenta in cercetarea interdisciplinarala Universitatea din Bucuresti (University of Bucharest, Romania) [CNFIS-FDI-2024-F-0484]en_US
dc.description.sponsorshipThis work was supported by a grant from the Ministry of Research, Innovation and Digitalization, CCCDI-UEFISCDI, project number PN-III-P2-2.1-PED-2021-2917 (622PED/2022), within PNCDI III. We acknowledge the support of the project CNFIS-FDI-2024-F-0484 INOVEX: Susttinerea Dezvoltarii unor noi competente si instrumente inovative pentru excelenta in cercetarea interdisciplinarala Universitatea din Bucuresti (University of Bucharest, Romania).en_US
dc.identifier.doi10.3390/polym16121627
dc.identifier.issn2073-4360
dc.identifier.issue12en_US
dc.identifier.pmid38931977en_US
dc.identifier.scopus2-s2.0-85197165317en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/polym16121627
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12862
dc.identifier.volume16en_US
dc.identifier.wosWOS:001256663400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofPolymersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectwound healingen_US
dc.subjectbiomaterialsen_US
dc.subjectcurcuminen_US
dc.subjectquercetinen_US
dc.subjectcollagenen_US
dc.subjectsilk sericinen_US
dc.subjecttissue regenerationen_US
dc.titleDevelopment and Investigation of an Innovative 3D Biohybrid Based on Collagen and Silk Sericin Enriched with Flavonoids for Potential Wound Healing Applicationsen_US
dc.typeArticleen_US

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