The expressions of AMACR and iNOS in prostate adenocarcinomas

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dc.contributor.authorOzgur, Tumay
dc.contributor.authorAtik, Esin
dc.contributor.authorHakverdi, Sibel
dc.contributor.authorYaldiz, Mehmet
dc.date.accessioned2024-09-18T20:55:30Z
dc.date.available2024-09-18T20:55:30Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground and Objective: Prostate cancer is the second leading cause of death in men. The localized disease often responds to conventional therapies like androgen ablation via castration and/or administration of chemical inhibitors but advanced disease resistant to any curative therapies is still challenge for investigators. There are increasing efforts to enhance the possibility of finding positive and sensitive immune markers for diagnosing and treating prostate cancer. The aim of this study was to investigate the expression patterns of AMACR and iNOS in prostate adenocarcinomas with different histopathologic grade. Methodology: We applied immunohistochemical markers; AMACR and iNOS. Formalin-fixed parafin embedded tissues of 64 prostate needle biopsy specimens diagnosed as prostate adenocarcinoma between 2005-2010 years were included in the study. Results: AMACR expression were found in 58 (90.6%) and iNOS expression in 54 (84.4%) of 64 prostate adenocarcinomas. No significant relationship of AMACR and iNOS was obtained (p > 0.05). There was no significant correlation of histopathologic grade of the tumors with AMACR and iNOS expression (p > 0.05). Conclusions: The expression of AMACR and iNOS might be important diagnostic immune markers for prostate adenocarcinomas especially in needle biopsies where the quantity and quality of tissue are limited.en_US
dc.description.sponsorshipMustafa Kemal University Scientific Research Project Board [1202M0106]en_US
dc.description.sponsorshipThis study was supported by Mustafa Kemal University Scientific Research Project Board with project number 1202M0106.en_US
dc.identifier.doi10.12669/pjms.292.2813
dc.identifier.endpage613en_US
dc.identifier.issn1682-024X
dc.identifier.issue2en_US
dc.identifier.pmid24353588en_US
dc.identifier.scopus2-s2.0-84875132793en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage610en_US
dc.identifier.urihttps://doi.org/10.12669/pjms.292.2813
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11869
dc.identifier.volume29en_US
dc.identifier.wosWOS:000318758900037en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherProfessional Medical Publicationsen_US
dc.relation.ispartofPakistan Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectProstateen_US
dc.subjectadenocarcinomaen_US
dc.subjectAMACRen_US
dc.subjectiNOSen_US
dc.titleThe expressions of AMACR and iNOS in prostate adenocarcinomasen_US
dc.typeArticleen_US

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