Genomic copy number alteration of glycolytic pathway in endometrial cancer

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dc.authoridCine, Naci/0000-0001-9063-1073
dc.contributor.authorYilmaz, M.
dc.contributor.authorAkkoyunlu, D. S.
dc.contributor.authorKeskin, S. E.
dc.contributor.authorDoger, E.
dc.contributor.authorCine, N.
dc.contributor.authorSavli, H.
dc.date.accessioned2024-09-18T20:13:20Z
dc.date.available2024-09-18T20:13:20Z
dc.date.issued2019
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractMetabolic reprogramming is one of the hallmarks of cancer cells, but very little is known about the difference in the expression of metabolic genes between cancer and normal tissues. The degree to which different cancer types display similar metabolic alteration is poorly understood. The best-known example of metabolic disturbance in cancer cells is the Warburg effect. The Warburg effect is the phenomenon of the cancer cells favoring the anaerobic glycolysis even in the presence of oxygen. It is displayed by most cancer cells. Although the genomic, transcriptomic, and proteomic studies have been published, metalobomic differences are still a major gap in our knowledge. Among women the most common malignancy is endometrial cancer. In this retrospective study, the authors investigated the genomic instability of glycolytic genes in endometrial carcinoma patients using array-based comparative genomic hybridization (aCGH) reports. The results indicate that among 54 patients diagnosed with endometrial carcinoma, in 21 patients, pathogenic genomic instability was detected which are linked with the disease. Among the 21 patients who had genomic instability, 19 of them (90.5%) displayed copy number variations of at least one or more glycolysis genes based on the genomic laboratory reports of the patients.en_US
dc.identifier.doi10.12892/ejgo4765.2019
dc.identifier.endpage646en_US
dc.identifier.issn0392-2936
dc.identifier.issn2709-0086
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85072129543en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage640en_US
dc.identifier.urihttps://doi.org/10.12892/ejgo4765.2019
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9107
dc.identifier.volume40en_US
dc.identifier.wosWOS:000474853300023en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMre Pressen_US
dc.relation.ispartofEuropean Journal of Gynaecological Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCopy number variationen_US
dc.subjectCopy number alterationen_US
dc.subjectEndometrial canceren_US
dc.subjectGlycolytic pathwayen_US
dc.subjectMetabolismen_US
dc.subjectComparative genomic hybridization (aCGH)en_US
dc.subjectGenomic instabilityen_US
dc.titleGenomic copy number alteration of glycolytic pathway in endometrial canceren_US
dc.typeArticleen_US

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