Protective agent, erdosteine, against cisplatin-induced hepatic oxidant injury in rats

Basit Öğe Kaydı
dc.authoridAkcan, Ramazan/0000-0002-4100-9488
dc.contributor.authorKoc, A
dc.contributor.authorDuru, M
dc.contributor.authorCiralik, H
dc.contributor.authorAkcan, R
dc.contributor.authorSogut, S
dc.date.accessioned2024-09-18T20:11:27Z
dc.date.available2024-09-18T20:11:27Z
dc.date.issued2005
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractCisplatin, one of the most active cytotoxic agents against cancer, has several toxicities. Hepatotoxicity is one of them occurred during high doses treatment. The aim of this study was to determine the effects of erdosteine against cisplatin-induced liver injury through tissue oxidant/antioxidant parameters and light microscopic evaluation. The rats were randomly divided into three groups: control (n=5), cisplatin (10 mg/kg, n=6) and cisplatin+erdosteine (50 mg/kg/day oral erdosteine, n=8) groups. The rats were sacrificed at the 5th day of cisplatin treatment. The liver tissues were examined with light microscopy and oxidant/antioxidant biochemical parameters. The malondialdehyde (MDA) and nitric oxide (NO) levels were increased in the cisplatin group in comparison with the control and cisplatin+erdosteine groups (p < 0.05). There was no significant difference in MDA and NO levels between control and cisplatin+erdosteine groups. The activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) were higher in cisplatin+erdosteine group than cisplatin group (p < 0.05). However, the CAT and GSH-Px activities were significantly lower in cisplatin group than in control group (p < 0.05). The light microscopic examination revealed that cytoplasmic changes especially around cells of central vein were observed in cisplatin group. Hepatocellular vacuolization was seen in these cells. In the cisplatin plus erdosteine group, a decrease in cytoplasmic changes with the hepatocytes and sinusoidal dilatations around cells of central vein were noticed in as compared to cisplatin group. In the light of microscopic and biochemical results, it was concluded that cisplatin-induced liver damage in high dose and erdosteine prevented this toxic side effect by the way of its antioxidant and radical scavenging effects.en_US
dc.identifier.doi10.1007/s11010-005-6630-z
dc.identifier.endpage84en_US
dc.identifier.issn0300-8177
dc.identifier.issn1573-4919
dc.identifier.issue1-2en_US
dc.identifier.pmid16180092en_US
dc.identifier.scopus2-s2.0-26444451680en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage79en_US
dc.identifier.urihttps://doi.org/10.1007/s11010-005-6630-z
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8865
dc.identifier.volume278en_US
dc.identifier.wosWOS:000232056600011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular and Cellular Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcisplatinen_US
dc.subjectlight microscopyen_US
dc.subjecterdosteineen_US
dc.subjectliveren_US
dc.subjectoxidant/antioxidanten_US
dc.titleProtective agent, erdosteine, against cisplatin-induced hepatic oxidant injury in ratsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
8865.pdf
Boyut:
288.42 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu