Impact of ellagic acid on adriamycin-induced testicular histopathological lesions, apoptosis, lipid peroxidation and sperm damages

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dc.authoridTurk, Gaffari/0000-0001-7417-1038
dc.authoridCeribasi, Ali Osman/0000-0002-6096-4042
dc.authoridATESSAHIN, Ahmet/0000-0002-1004-2146
dc.contributor.authorCeribasi, Ali Osman
dc.contributor.authorSakin, Fatih
dc.contributor.authorTurk, Gaffari
dc.contributor.authorSonmez, Mustafa
dc.contributor.authorAtessahin, Ahmet
dc.date.accessioned2024-09-18T19:50:24Z
dc.date.available2024-09-18T19:50:24Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of the present study was to investigate whether ellagic acid (EA) has protective effect on adriamycin (ADR)-induced testicular and spermatozoal toxicity associated with the oxidative stress in male rats. Thirthy-two healthy 8-week-old male Sprague-Dawley rats were equally divided into four groups. The first (EA) group was treated with EA (2 mg/kg/every other day) by gavage. The second (ADR) group received ADR (2 mg/kg/once a week) intraperitoneally, while the combination of ADR and EA was given to the third (ADR+EA) group. The forth (control) group was treated with placebo. At the end of the 8-week treatment period, reproductive organ weights, epididymal sperm parameters, histopathological changes and apoptosis via Bax and Bcl-2 proteins, testicular tissue lipid peroxidation, and antioxidant enzyme activities, were investigated. ADR administration was determined to cause significant decreases in reproductive organ weights, epididymal sperm concentration and motility, plasma testosterone concentration, diameter of seminiferous tubules, germinal cell layer thickness Johnsen's testicular score and Bcl-2 positive antiapoptotic cell rate, wherease it caused significant increases in level of lipid peroxidation and glutathione, catalase activity, abnormal sperm rates and Bax positive apoptotic cell rates along with degeneration, necrosis, immature germ cells, congestion and atrophy in testicular tissue when compared with the control group. EA administration to ADR-treated rats provided significant improvements in ADR-induced disturbed oxidant/antioxidant balance, decreased testosterone concentration, testicular apoptosis and mild improvements in the histopathological view of the testicular tissue. However. EA failed to improve decreased reproductive organ weights and deteriorated sperm parameters due to ADR administration. It is concluded that while ADR has direct or indirect (lipid peroxidation) negative effects on sperm structure and testicular apoptosis in rats, EA has protective effects on ADR-induced testicular lipid peroxidation and apoptosis. (C) 2011 Elsevier GmbH. All rights reserved.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [106O123]en_US
dc.description.sponsorshipThe authors acknowledge for financial support from The Scientific and Technological Research Council of Turkey (TUBITAK); Project number: 106O123. Additionally, the authors wish to express their gratitude to Prof. Dr. Burhan Cetinkaya, Department of Microbiology, Faculty of Veterinary Medicine, Firat University, Elazig, TURKEY, for revising the language of the manuscript.en_US
dc.identifier.doi10.1016/j.etp.2011.01.006
dc.identifier.endpage724en_US
dc.identifier.issn0940-2993
dc.identifier.issue7-8en_US
dc.identifier.pmid21295454en_US
dc.identifier.scopus2-s2.0-84867708513en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage717en_US
dc.identifier.urihttps://doi.org/10.1016/j.etp.2011.01.006
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7420
dc.identifier.volume64en_US
dc.identifier.wosWOS:000311073100008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Gmbh, Urban & Fischer Verlagen_US
dc.relation.ispartofExperimental and Toxicologic Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdriamycinen_US
dc.subjectEllagic aciden_US
dc.subjectLipid peroxidationen_US
dc.subjectTesticular apoptosisen_US
dc.subjectSperm characteristicsen_US
dc.titleImpact of ellagic acid on adriamycin-induced testicular histopathological lesions, apoptosis, lipid peroxidation and sperm damagesen_US
dc.typeArticleen_US

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