The androgenic profile of women with non-insulin-dependent diabetes mellitus

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dc.contributor.authorTok, EC
dc.contributor.authorErtunc, D
dc.contributor.authorEvruke, C
dc.contributor.authorDilek, S
dc.date.accessioned2024-09-18T21:07:59Z
dc.date.available2024-09-18T21:07:59Z
dc.date.issued2004
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOBJECTIVE: To evaluate the androgenic profile of women with non-insulin-dependent diabetes mellitus. STUDY DESIGN: This case-control study evaluated the clinical, hormonal and ultrasonographic characteristics of women of reproductive age with non-insulin-dependent diabetes mellitus and compared them with those of age- and weight-matched controls. Radioimmunoassays were used for total testosterone, estradiol, dehydroepiandrosterone sulfate (DHEAS) and androstenedione. Sex hormone-binding globulin (SHBG), luteinizing hormone (LH) and follicle stimulating hormone (FSH) were analyzed by fluoroimmunoassays. Ovarian appearance and volume were assessed by transvaginal or transabdominal ultrasonography. RESULTS: The prevalence of polycystic ovary syndrome was higher in diabetic patients than in the general population as reported earlier. Hirsutism was also more prevalent in diabetic patients (p < 0.05). The serum levels of FSH, LH, estradiol, total testosterone, androstenedione and DHEAS were significantly higher in diabetic patients than in the control group (p < 0.05). In contrast, the levels of SHBG were lower in diabetic patients (p < 0.05). The rates of ultrasonographically apparent polycystic ovaries and greater ovarian volumes were also higher in diabetic patients (p < 0.05). CONCLUSION: Women with non-insulin-dependent diabetes mellitus seem to have biochemical and clinical hyperandrogenism when compared with nondiabetic controls.en_US
dc.identifier.endpage752en_US
dc.identifier.issn0024-7758
dc.identifier.issn1943-3565
dc.identifier.issue9en_US
dc.identifier.pmid15493567en_US
dc.identifier.startpage746en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14067
dc.identifier.volume49en_US
dc.identifier.wosWOS:000224110300010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofJournal of Reproductive Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPolycystic-Ovary-Syndromeen_US
dc.subjectAdrenal Steroidogenesisen_US
dc.subjectRisk-Factorsen_US
dc.subjectYoung Womenen_US
dc.subjectPrevalenceen_US
dc.subjectResistanceen_US
dc.subjectHyperandrogenismen_US
dc.subjectDysregulationen_US
dc.subjectSecretionen_US
dc.subjectHyperinsulinemiaen_US
dc.titleThe androgenic profile of women with non-insulin-dependent diabetes mellitusen_US
dc.typeArticleen_US

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