Design, synthesis and antiproliferative activity evaluation of fluorine-containing chalcone derivatives

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dc.authoridKILIC, DERYANUR/0000-0002-9115-136X
dc.contributor.authorBurmaoglu, Serdar
dc.contributor.authorAktas Anil, Derya
dc.contributor.authorGobek, Arzu
dc.contributor.authorKilic, Deryanur
dc.contributor.authorYetkin, Derya
dc.contributor.authorDuran, Nizami
dc.contributor.authorAlgul, Oztekin
dc.date.accessioned2024-09-18T20:59:14Z
dc.date.available2024-09-18T20:59:14Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractA series of new chalcones containing fluoro atom at B ring have been designed, synthesized, and evaluated to be antiproliferative activity against a panel of human tumor cell lines. Some of the analogs (8, 9, 12, 45, 46 and 48) displayed powerful antiproliferative effects to certain human tumor cells, but all of them were devoid of any cytotoxicity towards the normal HEK 293. Acridine orange staining data supported that the cytotoxic and antiproliferative effects of the synthesized analogs on tumor cells are mediated through apoptosis. The compounds 12 and 46 manifested concentration-dependent antiproliferative activity in human hepatocellular carcinoma cell lines using an xCELLigence assay. The structures and antiproliferative activity relationship were further supported by in silico molecular docking study of the compounds against tubulin protein which suggests our compounds interference to cell division. Communicated by Ramaswamy H. Sarmaen_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey; Scientific and Technological Research Council of Turkey (TUBITAK) [114Z554]en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey 10.13039/501100004410 We thank the Scientific and Technological Research Council of Turkey (TUBITAK Grant Number: 114Z554).en_US
dc.identifier.doi10.1080/07391102.2020.1848627
dc.identifier.endpage3550en_US
dc.identifier.issn0739-1102
dc.identifier.issn1538-0254
dc.identifier.issue8en_US
dc.identifier.pmid33200677en_US
dc.identifier.scopus2-s2.0-85096187868en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3525en_US
dc.identifier.urihttps://doi.org/10.1080/07391102.2020.1848627
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12467
dc.identifier.volume40en_US
dc.identifier.wosWOS:000589852300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Biomolecular Structure & Dynamicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSynthesisen_US
dc.subjectChalconeen_US
dc.subjectMTTen_US
dc.subjectantiproliferative activityen_US
dc.subjectflour effecten_US
dc.titleDesign, synthesis and antiproliferative activity evaluation of fluorine-containing chalcone derivativesen_US
dc.typeArticleen_US

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