Effect of sulfite on antioxidant enzymes and lipid peroxidation in normal and sulfite oxidase-deficient rat erythrocytes

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dc.authoridOktar, Suleyman/0000-0003-0151-5981
dc.authoridKUCUKATAY, VURAL/0000-0002-6850-6281
dc.contributor.authorOzturk, Oktay Hasan
dc.contributor.authorOktar, Suleyman
dc.contributor.authorAydin, Mehmet
dc.contributor.authorKucukatay, Vural
dc.date.accessioned2024-09-18T20:59:11Z
dc.date.available2024-09-18T20:59:11Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractSulfite and related chemical such as sulfite salts and sulfur dioxide has been used as a preservative in food and drugs. This molecule has also been generated from the catabolism of sulfur-containing amino acids. Sulfite is a very reactive and potentially toxic molecule and has to be detoxified by the enzyme sulfite oxidase (SOX). The aim of this study was to investigate the effects of ingested sulfite on erythrocyte antioxidant status by measuring glucose-6-phosphate dehydrogenase (G-6-PD), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities and oxidant status by measuring thiobarbituric acid reactive substances (TBARS) in normal and SOX-deficient rats. Rats were assigned to four groups (n = 10 rats/group) as follows; control (C), sulfite (CS), deficient (D), and deficient+sulfite (DS). SOX deficiency was established by feeding rats a low molybdenum diet and adding to their drinking water 200 ppm tungsten (W). Sulfite (25 mg/kg) was administered to the animals via their drinking water. At the end of 6 weeks, Erythrocyte G-6-PD, SOD, and GPx but not CAT activities were found to be significantly increased with and without sulfite treatment in SOX-deficient groups. Sulfite treatment alone was also significantly increased erythrocytes' SOD activity in CS group compared to control. TBARS levels were found to be significantly increased in CS and DS groups and decreased in D group. When SOX-deficient rats treated with sulfite, TBARS level was still higher than other groups. In conclusion, these results suggested that erythrocyte antioxidant capacity, a defense mechanism against the oxidative challenge, increased by endogenous and exogenous sulfite due to its oxidant nature. This increase was also observed in CS and DS groups but it was insufficient to prevent lipid peroxidation.en_US
dc.identifier.doi10.1007/s13105-010-0025-7
dc.identifier.endpage212en_US
dc.identifier.issn1138-7548
dc.identifier.issn1877-8755
dc.identifier.issue3en_US
dc.identifier.pmid20571963en_US
dc.identifier.scopus2-s2.0-78349303088en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage205en_US
dc.identifier.urihttps://doi.org/10.1007/s13105-010-0025-7
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12433
dc.identifier.volume66en_US
dc.identifier.wosWOS:000284061300003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Physiology and Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSulfiteen_US
dc.subjectAntioxidantsen_US
dc.subjectLipid peroxidationen_US
dc.subjectErythrocyteen_US
dc.subjectRaten_US
dc.titleEffect of sulfite on antioxidant enzymes and lipid peroxidation in normal and sulfite oxidase-deficient rat erythrocytesen_US
dc.typeArticleen_US

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