The Relationship between Serum IL-17 and IL-23 Levels, and Other Disease Activity Parameters in Patients with Behcet's Disease

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dc.authoridkucuksahin, orhan/0000-0003-4530-2304
dc.contributor.authorKucuksahin, O.
dc.contributor.authorSahin, A.
dc.contributor.authorYildizgoren, M. T.
dc.contributor.authorTurgay, M.
dc.contributor.authorKinikli, G.
dc.date.accessioned2024-09-18T20:04:22Z
dc.date.available2024-09-18T20:04:22Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: To investigate the relationship between disease activity and the involvement of Behcet's disease (BD) and serum levels of interleukin (IL)-17 and IL-23. Methods: Sixty patients with BD and 20 healthy control group subjects were included in this study. The patients were divided into four groups according to clinical findings as follows: entero-Behcet, mucocutaneous-Behcet, neuro-Behcet and vascular-Behcet. The serum levels of the IL-17 and IL-23 levels were evaluated using enzyme-linked immunosorbent assay. Results: Of the BD patients, 15 (25%) had active disease and 45 (75%) had inactive disease. The serum levels of IL-23 and IL-17 were statistically significantly higher in the patients with BD than in the control groups (p < 0.05). A significant relationship was also observed between the disease activity, and both the erythrocyte sedimentation rate and the C-reactive protein levels (p < 0.05). The mean serum levels of IL-17 and IL-23 in patients with active disease were 0.07 0.25 pg/ml and 36.0 30.5 pg/ml, respectively. There was no statistically significant relationship between the disease activity and the serum levels of IL-17 and IL-23 (p > 0.05). There were also statistically significant relationships between the disease activity and uveitis, retinal vasculitis or superficial thrombophlebitis. Conclusion: No relationship was found between BD and serum levels of the IL-17 and the IL-23.en_US
dc.identifier.doi10.7727/wimj.2015.248
dc.identifier.endpage627en_US
dc.identifier.issn0043-3144
dc.identifier.issn2309-5830
dc.identifier.issue9en_US
dc.identifier.scopus2-s2.0-85165118655en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage624en_US
dc.identifier.urihttps://doi.org/10.7727/wimj.2015.248
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8119
dc.identifier.volume69en_US
dc.identifier.wosWOS:000916510100006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniv West Indies Faculty Medical Sciencesen_US
dc.relation.ispartofWest Indian Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBehcet's diseaseen_US
dc.subjectinterleukin-17en_US
dc.subjectinterleukin-23en_US
dc.titleThe Relationship between Serum IL-17 and IL-23 Levels, and Other Disease Activity Parameters in Patients with Behcet's Diseaseen_US
dc.typeArticleen_US

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