Metformin and parameters of physical health

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dc.contributor.authorHelvaci, Mehmet Rami
dc.contributor.authorKaya, Hasan
dc.contributor.authorBorazan, Ali
dc.contributor.authorOzer, Cahit
dc.contributor.authorSeyhanli, Mahmut
dc.contributor.authorYalcin, Atilla
dc.date.accessioned2024-09-18T20:32:49Z
dc.date.available2024-09-18T20:32:49Z
dc.date.issued2008
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground The prevalence of excess weight, including overweight and obesity, is increasing with a high cost on health in society. Methods Consecutive cases with excess weight, aged between 50 and 70 years and desiring weight loss, were divided into two subgroups according to wishes of patients about whether they prefer medication or just a diet. Metformin at a daily dose of 2,550 mg was given to the medication group. Results As for the very high prevalences, 84.8% (313/369) of cases at or above the age of 50 years were overweight or obese, 67.2% (248/369) of them had white coat hypertension (WCH)or hypertension (HT), 52.5% (194/369) of them had impaired glucose tolerance (IGT) or diabetes mellitus (DM), and 68.8% (254/369) of them had dyslipidemia. Initially 143 cases with excess weight preferred the diet and 162 of them preferred the metformin therapy. But 42 cases (25.9%) stopped the drug because of excessive anorexia. At the end of the six-month period, there were highly significant differences between the two groups according to prevalences of resolved WCH, hyperbetalipoproteinemia, hypertriglyceridemia, dyslipidemia, overweight, and obesity and a decreased fasting plasma glucose below 110 mg/dL (p < 0.001 for all). Conclusion Due to the very high prevalences of excess weight and probably many associated disorders with the excess weight, including IGT or DM, WCH or HT, and dyslipidemia, above the age of 50 years, and the detected significant benefits of metformin on all of the above parameters, metformin treatment should be initiated in patients with excess weight in their fifties.en_US
dc.identifier.doi10.2169/internalmedicine.47.0787
dc.identifier.endpage703en_US
dc.identifier.issn0918-2918
dc.identifier.issn1349-7235
dc.identifier.issue8en_US
dc.identifier.pmid18421184en_US
dc.identifier.scopus2-s2.0-44649098532en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage697en_US
dc.identifier.urihttps://doi.org/10.2169/internalmedicine.47.0787
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11145
dc.identifier.volume47en_US
dc.identifier.wosWOS:000258893800003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJapan Soc Internal Medicineen_US
dc.relation.ispartofInternal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmetforminen_US
dc.subjectexcess weighten_US
dc.subjectfifty years of ageen_US
dc.titleMetformin and parameters of physical healthen_US
dc.typeArticleen_US

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