Protective effects of thymoquinone on vancomycin-induced nephrotoxicity in rats

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dc.contributor.authorBasarslan, F.
dc.contributor.authorYilmaz, N.
dc.contributor.authorAtes, S.
dc.contributor.authorOzgur, T.
dc.contributor.authorTutanc, M.
dc.contributor.authorMotor, V. K.
dc.contributor.authorArica, V.
dc.date.accessioned2024-09-18T21:00:32Z
dc.date.available2024-09-18T21:00:32Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim: Oxidative stress has been implicated as a potential responsible mechanism in the pathogenesis of vancomycin (VCM)-induced renal toxicity. Therefore, we aimed to investigate the protective effect of thymoquinone (TQ) against VCM-induced nephrotoxicity by tissue oxidant/antioxidant parameters and histological changes in rats. Materials and methods: Wistar albino rats were randomly separated into four groups consisting of seven rats per group. The groups had normal saline (control group), VCM, VCM and TQ and TQ, respectively. VCM was injected intraperitoneally at a dose of 200 mg/kg and continued at 12-h intervals for 7 days. TQ was injected intraperitoneally at a dose of 10 mg/kg and continued at 24 h intervals for 8 days. Animals were killed and blood samples were analyzed for the levels of serum blood urea nitrogen (BUN) and creatinine (Cr). Kidney specimens were analyzed for levels of malondialdehyde (MDA) and activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) as well as for histopathological changes. Results: We found that the levels of serum BUN, Cr and kidney tissue MDA were increased in the VCM group. Activities of SOD and GSH-Px in kidney tissue were decreased. TQ administration ameliorated significantly these changes. Conclusion: These results indicate that the TQ produces a protective mechanism against VCM-induced nephrotoxicity and suggest a role of oxidative stress in pathogenesis.en_US
dc.identifier.doi10.1177/0960327111433185
dc.identifier.endpage733en_US
dc.identifier.issn0960-3271
dc.identifier.issue7en_US
dc.identifier.pmid22318306en_US
dc.identifier.scopus2-s2.0-84864120336en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage726en_US
dc.identifier.urihttps://doi.org/10.1177/0960327111433185
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12747
dc.identifier.volume31en_US
dc.identifier.wosWOS:000306483900010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectvancomycinen_US
dc.subjectthymoquinoneen_US
dc.subjectnephrotoxicityen_US
dc.subjectoxidative stressen_US
dc.titleProtective effects of thymoquinone on vancomycin-induced nephrotoxicity in ratsen_US
dc.typeArticleen_US

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