Acute oxidant and inflammatory effects of imidacloprid on the mammalian central nervous system and liver in rats

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dc.contributor.authorDuzguner, Vesile
dc.contributor.authorErdogan, Suat
dc.date.accessioned2024-09-18T20:27:57Z
dc.date.available2024-09-18T20:27:57Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractImidacloprid is a neonicotinoid insecticide and has been extensively used as a crop pest and pet flea control programme because it's high specificity as an insecticide Imidacloprid toxicity on mammalian tissues has not been adequately evaluated In the present study, potential acute neuro and liver toxic effects of imidacloprid were analyzed in rats as a model of mammalian using antioxidant-oxidant and inflammatory system 10 mu M imidacloprid was administrated intravenously and 2 h post-administration, the rats were sacrificed, liver and brains were surgically removed Exposure to imidacloprid led to significant increases in nitric oxide concentrations in brain, liver and plasma samples The quantitative mRNA transcriptional analyses demonstrated that imidacloprid-elevated production of NO levels due to the induction of NOS in liver, but neither nNOS nor iNOS were induced in brain The oxidant-generating enzymes xanthine oxidase and myeloperoxidase activities in both tissues were elevated and significant lipid peroxidation in liver and plasma was observed The antioxidant catalase, superoxide dismutase and glutathione peroxidase activities were differently responded to imidacloprid administration Significant intracellular glutathione depletion was also measured in both tissues Imidacloprid treatment up-regulated inflammatory cytokmes TNF-alpha, IL-6 and IL-1 beta mRNA transcriptions by 2 5- to 5 2-fold increases in both brain and liver Conversely, anti-inflammatory mediator IL-10 mRNA was down-regulated in both organs These results suggest that imidacloprid cause oxidative stress and inflammation in central nervous system and liver in non-target organisms in rats (C) 2009 Elsevier Inc All rights reserveden_US
dc.description.sponsorshipMustafa Kemal University, Scientific Research Projects Committee [08L0201]en_US
dc.description.sponsorshipThis work was financially supported by Mustafa Kemal University, Scientific Research Projects Committee (Project No. 08L0201). Authors thank Prof. George Theophilidis (Thessalonniki, Greece) for his helpful discussions and Altug Kucukgul (Antakya, Turkey) for his technical assistanceen_US
dc.identifier.doi10.1016/j.pestbp.2009.11.008
dc.identifier.endpage18en_US
dc.identifier.issn0048-3575
dc.identifier.issn1095-9939
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-77950593848en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage13en_US
dc.identifier.urihttps://doi.org/10.1016/j.pestbp.2009.11.008
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10637
dc.identifier.volume97en_US
dc.identifier.wosWOS:000277106100003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofPesticide Biochemistry and Physiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectImidaclopriden_US
dc.subjectNeonicotinoiden_US
dc.subjectOxidative stressen_US
dc.subjectInflammationen_US
dc.subjectInsecticideen_US
dc.titleAcute oxidant and inflammatory effects of imidacloprid on the mammalian central nervous system and liver in ratsen_US
dc.typeArticleen_US

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