Phthalates in commonly used pharmaceuticals

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dc.authoridCiran, Mutasim/0000-0003-2160-4121
dc.authoridSungur, Sana/0000-0001-7370-8972
dc.authoridTURGUT, FARUK/0000-0003-1910-7433
dc.contributor.authorSungur, Sana
dc.contributor.authorCiran, Mutasim
dc.contributor.authorKoroglu, Muaz
dc.contributor.authorTurgut, F. Hilmi
dc.date.accessioned2024-09-18T20:54:14Z
dc.date.available2024-09-18T20:54:14Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPhthalates are man-made, endocrine disrupting chemicals that are commonly used in plastics, medical applications, drugs, personal care products, cosmetics, perfumes, home furnishings, dyes, children's toys, food packaging. Animal studies have revealed that phthalates have many adverse health effects. Since phthalates do not dissolve in acidic environments, they are only soluble in neutral or basic environments, they are frequently used in gastro-resistant film coatings of drugs that are not intended to dissolve in the stomach and that need to be dissolved directly in the intestine. Within the scope of this study, phthalates and their amounts in frequently used drugs in our country were determined by GC-MS and the potential health risks of patients using such drugs were evaluated. It was determined that the total phthalate concentrations in the examined drug samples ranged between 0.209 and 4.800 mg kg(-1), and the amounts in a single tablet ranged between 2.7x 10(-5) and 1.5x 10(-3 )mg/tablet. The highest concentrations of total phthalate were found in cholesterol (4.800 mg kg(-1)) and blood pressure lowering drugs (4.442 mg kg(-1)). The calculated hazard index values were found to be less than one. This showed that the phthalates detected in the drugs examined did not pose a risk to human health.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Mustafa Kemal University [20.YL.008]en_US
dc.description.sponsorshipThis research [20.YL.008] was supported by the Scientific Research Projects Coordination Unit of Mustafa Kemal University.en_US
dc.identifier.doi10.1080/15569543.2022.2094415
dc.identifier.endpage263en_US
dc.identifier.issn1556-9543
dc.identifier.issn1556-9551
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85133284783en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage257en_US
dc.identifier.urihttps://doi.org/10.1080/15569543.2022.2094415
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11688
dc.identifier.volume42en_US
dc.identifier.wosWOS:000819544700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofToxin Reviewsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPhthalateen_US
dc.subjectmedicineen_US
dc.subjectpharmaceuticalen_US
dc.subjectendocrine disruptoren_US
dc.subjectGC-MSen_US
dc.titlePhthalates in commonly used pharmaceuticalsen_US
dc.typeArticleen_US

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