The influence of Theranekron® on glucose-6-phosphate dehydrogenase activity in rat ovaries, intact and with ischemia-reperfusion injury

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dc.authoridASLAN, ERDOGAN/0000-0002-9573-5688
dc.contributor.authorKozlu, Tolunay
dc.contributor.authorGuler, Fatma
dc.contributor.authorAkalin, Pinar Peker
dc.contributor.authorKazak, Filiz
dc.contributor.authorErgun, Yasar
dc.contributor.authorAslan, Erdogan
dc.date.accessioned2024-09-18T20:59:22Z
dc.date.available2024-09-18T20:59:22Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe effect of Theranekron (R) on rat ovaries was evaluated in healthy and ischemia-reperfusion injury models. The rats were divided into four groups: group 1: control, group 2: Theranekron (R) (single dose of 0.3 mg/kg intraperitoneally), group 3: torsion + detorsion, and group 4: torsion + detorsion + Theranekron (R) (single dose 0,3 mg/kg. intraperitoneally). The ovaries were homogenized by sonication before the analysis and supernatant glucose-6-phosphate dehydrogenase activity, reduced nicotinamide adenine dinucleotide phosphate, reduced glutathione and total protein levels were evaluated spectrophotometrically. Ovary tissues were histologically examined. In group 2, glucose-6-phosphate dehydrogenase activity was significantly reduced (P<0.01) compared to the control group and an increased number of atretic follicles, and hyperaemic and haemorrhagic regions were seen histologically: in group 3. although glucose-6-phosphate dehydrogenase activity was not changed, intense hyperaemia and hemorrhage was observed in the veins of the medulla region and in the cortex. Group 4 showed a decrease in glucose-6-phosphate dehydrogenase activity compared to the control group (P<0.01). Histologically, when compared to group 3, group 4 showed fewer atretic follicles and decreased hyperaemia and hemorrhage in the ovaries, excluding the medulla region. There were no significant differences regarding reduced glutathione and reduced nicotinamide adenine dinucleotide phosphate levels between the groups. The Theranekron (R) dose applied had some negative effects, such as reduced glucose-6-phosphate dehydrogenase activity. an increased number of atretic follicles, and hyperemia in the corpus luteum and medulla region in intact rat ovaries. Although it reduced glucose-6-phosphate dehydrogenase activity, Theranekron (R) may have had slight remedial effects on rat ovaries with ischemia-reperfusion injury.en_US
dc.description.sponsorship[12241]en_US
dc.description.sponsorshipThis study was produced by the Hatay Mustafa Kemal University Scientific Research Projects Unit as part of a thesis study supported by Project number 12241.en_US
dc.identifier.doi10.24099/vet.arhiv.0828
dc.identifier.endpage92en_US
dc.identifier.issn0372-5480
dc.identifier.issn1331-8055
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85104679248en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage85en_US
dc.identifier.urihttps://doi.org/10.24099/vet.arhiv.0828
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12541
dc.identifier.volume91en_US
dc.identifier.wosWOS:000621554500009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniv Zagreb Vet Facultyen_US
dc.relation.ispartofVeterinarski Arhiven_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTheranekron (R)en_US
dc.subjectovaryen_US
dc.subjectischemia-reperfusionen_US
dc.subjectglucose-6-phosphate dehydrogenaseen_US
dc.subjectraten_US
dc.titleThe influence of Theranekron® on glucose-6-phosphate dehydrogenase activity in rat ovaries, intact and with ischemia-reperfusion injuryen_US
dc.typeArticleen_US

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