Investigation of the prophylactic and therapeutic effectiveness of oral thyme extract in rats experimentally infected with cryptosporidium parvum

Basit Öğe Kaydı
dc.authoridKaya, Ufuk/0000-0002-4805-0993
dc.authoridDURU, OZKAN/0000-0002-8792-442X
dc.authoridKARA, Erdal/0000-0001-7047-9502
dc.authoridYasa Duru, Sibel/0000-0002-6803-6339
dc.authoridSENEL, YASIN/0000-0003-0272-2712
dc.authoridSevin, Sedat/0000-0003-0475-9092
dc.contributor.authorKara, Erdal
dc.contributor.authorDuru, Sibel Yasa
dc.contributor.authorGokpinar, Sami
dc.contributor.authorDuru, Ozkan
dc.contributor.authorSevin, Sedat
dc.contributor.authorSenel, Yasin
dc.contributor.authorKaya, Ufuk
dc.date.accessioned2024-09-18T20:13:35Z
dc.date.available2024-09-18T20:13:35Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIn this study, the prophylactic and therapeutic activities of thyme extract at different concentrations against experimental Cryptosporidium parvum infection in immunosuppressed rats were investigated. Thyme extract was prepared at four different concentrations (10%, 30%, 50%, and 100%) and administered as a single oral dose of 1 mL for evaluation of its prophylactic efficacy. Five consecutive days after infection was detected in all rats, therapeutic evaluations were also performed. According to the results obtained by daily counting of oocysts in stools, the prophylactic and therapeutic effects of thyme extract administration were significant in comparison to the control group (P<0.01). Oocyst shedding continued in the control group at high numbers from the beginning to the end of the study, while oocyst counts in the prophylaxis groups remained low throughout the study. On the other hand, oocyst excretion rates were high in the therapeutic groups and decreased rapidly after thyme extract administration. At the end of the study, oocyst excretion had completely stopped for some rats administered thyme extract. There was no group in which oocyst shedding ceased for all rats. No significant differences were observed in the therapeutic or prophylaxis groups regarding the doses administered (P > 0.01). Renal and hepatic functions were monitored by measuring urea, creatinine, alanine transaminase, and aspartate transaminase levels before and after thyme extract administration. As a result, it was concluded that oral thyme extract administration at the doses applied in this study is effective and safe in the prophylactic and therapeutic treatment of experimental cryptosporidiosis in rats.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Kirikkale University [2020/039]en_US
dc.description.sponsorshipThis work was supported by the Scientific Research Projects Coordination Unit of Kirikkale University (Project number 2020/039).en_US
dc.identifier.doi10.1007/s11259-022-10025-6
dc.identifier.endpage673en_US
dc.identifier.issn0165-7380
dc.identifier.issn1573-7446
dc.identifier.issue2en_US
dc.identifier.pmid36323839en_US
dc.identifier.scopus2-s2.0-85141193713en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage663en_US
dc.identifier.urihttps://doi.org/10.1007/s11259-022-10025-6
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9275
dc.identifier.volume47en_US
dc.identifier.wosWOS:000877986700002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofVeterinary Research Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCryptosporidium parvumen_US
dc.subjectDoseen_US
dc.subjectExtracten_US
dc.subjectProphylaxisen_US
dc.subjectRaten_US
dc.subjectThymeen_US
dc.subjectTreatmenten_US
dc.titleInvestigation of the prophylactic and therapeutic effectiveness of oral thyme extract in rats experimentally infected with cryptosporidium parvumen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu