The Investigation of Total PSA, Free PSA, and Free/Total PSA Ratio in Patients With Liver Cirrhosis Patients According to Child-Pugh Score

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dc.contributor.authorInci, Mehmet
dc.contributor.authorRifaioglu, Murat Mehmet
dc.contributor.authorInci, Melek
dc.contributor.authorCelik, Murat
dc.contributor.authorDemir, Mehmet
dc.contributor.authorUlutas, Turker
dc.contributor.authorDavarci, Mursel
dc.date.accessioned2024-09-18T21:03:11Z
dc.date.available2024-09-18T21:03:11Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOBJECTIVE To investigate the total prostate-specific antigen (tPSA), free PSA (fPSA), and free/total PSA (fPSA/tPSA) ratio in patients with liver cirrhosis (LC) according to the severity of hepatic insufficiency. METHODS Eighty-two male patients with LC were studied. The severity of liver disease was categorized by Child-Pugh score (Child-Pugh A, B, and C). Forty-two age-matched healthy subjects were used as a control group. The tPSA, fPSA, fPSA/tPSA ratio, total prostate volume (TPV), total testosterone (TT), and total protein (TP) were measured. The LC group was compared with the control group in terms of these parameters. In addition, intra-comparison and inter-comparison was made between all the Child-Pugh groups and normal subjects, in terms of these parameters. RESULTS The tPSA and fPSA levels in LC cases, Child-Pugh A, Child-Pugh B, and Child-Pugh C groups were significantly decreased compared with the control group. The ratio of fPSA/tPSA in the LC subjects and Child-Pugh A groups significantly increased compared with the control group. TT, TP levels, and TPV in patients with LC were significantly lower compared with the control group and the results were significantly correlated with the Child-Pugh score. CONCLUSION The present study reveals that tPSA and fPSA were decreased in patients with LC in comparison to healthy subjects in terms of 3 mechanisms. First, it might be due to shrunken prostatic volume. Second, it also resulted in decreased levels of testosterone because of the abnormality of hypothalamic-pituitary-testicular axis. Third, it might be the diminished serum protein level in the composition of the PSA. UROLOGY 81: 617-622, 2013. (c) 2013 Elsevier Inc.en_US
dc.identifier.doi10.1016/j.urology.2012.11.022
dc.identifier.endpage622en_US
dc.identifier.issn0090-4295
dc.identifier.issn1527-9995
dc.identifier.issue3en_US
dc.identifier.pmid23332995en_US
dc.identifier.scopus2-s2.0-84875366900en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage617en_US
dc.identifier.urihttps://doi.org/10.1016/j.urology.2012.11.022
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13296
dc.identifier.volume81en_US
dc.identifier.wosWOS:000315530800038en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofUrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProstate-Specific Antigenen_US
dc.subjectPartial Deficiencyen_US
dc.subjectHepatic Cirrhosisen_US
dc.subjectSerum-Levelsen_US
dc.subjectAlpha-1-Antichymotrypsinen_US
dc.subjectDiseaseen_US
dc.subjectCanceren_US
dc.subjectMenen_US
dc.titleThe Investigation of Total PSA, Free PSA, and Free/Total PSA Ratio in Patients With Liver Cirrhosis Patients According to Child-Pugh Scoreen_US
dc.typeArticleen_US

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