Ten millennia of hepatitis B virus evolution

Basit Öğe Kaydı
dc.authoridMannermaa, Kristiina/0000-0002-8510-1120
dc.authoridRivollat, Maite/0000-0002-4011-2862
dc.authoridLlamas, Bastien/0000-0002-5550-9176
dc.authoridVasiliev, Dmitry/0000-0003-2346-8856
dc.authoridrottier, stephane/0000-0002-1520-6648
dc.authoridTEJEDOR-RODRIGUEZ, CRISTINA/0000-0002-3156-0866
dc.authoridKussner, Mario/0000-0002-4915-0179
dc.contributor.authorKocher, Arthur
dc.contributor.authorPapac, Luka
dc.contributor.authorBarquera, Rodrigo
dc.contributor.authorKey, Felix M.
dc.contributor.authorSpyrou, Maria A.
dc.contributor.authorHubler, Ron
dc.contributor.authorRohrlach, Adam B.
dc.date.accessioned2024-09-18T21:05:26Z
dc.date.available2024-09-18T21:05:26Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractHepatitis B virus (HBV) has been infecting humans for millennia and remains a global health problem, but its past diversity and dispersal routes are largely unknown. We generated HBV genomic data from 137 Eurasians and Native Americans dated between similar to 10,500 and similar to 400 years ago. We date the most recent common ancestor of all HBV lineages to between similar to 20,000 and 12,000 years ago, with the virus present in European and South American hunter-gatherers during the early Holocene. After the European Neolithic transition, Mesolithic HBV strains were replaced by a lineage likely disseminated by early farmers that prevailed throughout western Eurasia for similar to 4000 years, declining around the end of the 2nd millennium BCE. The only remnant of this prehistoric HBV diversity is the rare genotype G, which appears to have reemerged during the HIV pandemic.en_US
dc.description.sponsorshipMax Planck Society; European Research Council (ERC) under the European Union [771234-PALEoRIDER, 805268-CoDisEASe, 834616-ARCHCAUCASUS]; Slovak Academy of Sciences; European Union's Seventh Framework Programme; Marie Curie Actions under the Programme SASPRO [1340/03/03]; ERA.NET RUS Plus-S&T programm of the European Union [277-BIOARCCAUCASUS]; Werner Siemens Stiftung; Award Praemium Academiae of the Czech Academy of Sciences; Institute of Archaeology of the Czech Academy of Sciences [RVO 67985912]; Russian Foundation for Basic Research [19-09-00354a, 19-78-10053]; German Research Foundation [DFG-HA-5407/4-1INTERACT, RE2688/2]; French National Research Agency [ANR-17-FRAL-0010-INTERACT]; Wenner-Gren Dissertation Fieldwork Grant [9558]; Ministry of Education and Science of the Republic of Kazakhstan [AP08856654, AP08857177]en_US
dc.description.sponsorshipThe research was funded by the Max Planck Society, the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (771234-PALEoRIDER, to W.H.; 805268-CoDisEASe to K. Bos; 834616-ARCHCAUCASUS to S.H.), the Slovak Academy of Sciences and the European Union's Seventh Framework Programme and Marie Curie Actions under the Programme SASPRO (1340/03/03 to P.C.R.), the ERA.NET RUS Plus-S&T programm of the European Union's Seventh Framework Programme (277-BIOARCCAUCASUS to S.Re. and S.H.), the Werner Siemens Stiftung (Paleobiochemistry, to CW), the Award Praemium Academiae of the Czech Academy of Sciences (to M.E.), the Institute of Archaeology of the Czech Academy of Sciences (RVO 67985912, to M.Dobe.), the Russian Foundation for Basic Research (19-09-00354a, to M.K.K. and V.V.K.; 19-78-10053 to SSh), the German Research Foundation (DFG-HA-5407/4-1INTERACT to W.H. and RE2688/2 to S.Re.), the French National Research Agency (ANR-17-FRAL-0010-INTERACT, to M.F.D., M.Ri., S.Ro., S.Sai., D.Bi., and P.Le.), the Wenner-Gren Dissertation Fieldwork Grant (9558 to S.Sab.), and the Ministry of Education and Science of the Republic of Kazakhstan (AP08856654 to L.B.D., L.M., and E.Kh. and AP08857177 to A.Z.B.).en_US
dc.identifier.doi10.1126/science.abi5658
dc.identifier.endpage+en_US
dc.identifier.issn0036-8075
dc.identifier.issn1095-9203
dc.identifier.issue6564en_US
dc.identifier.pmid34618559en_US
dc.identifier.scopus2-s2.0-85118031627en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage183en_US
dc.identifier.urihttps://doi.org/10.1126/science.abi5658
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13568
dc.identifier.volume374en_US
dc.identifier.wosWOS:000704920400041en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Assoc Advancement Scienceen_US
dc.relation.ispartofScienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAncient Human Genomesen_US
dc.subjectBronze-Ageen_US
dc.subjectGenotype-Gen_US
dc.subjectSubsistence Strategiesen_US
dc.subjectSalmonella-Entericaen_US
dc.subjectGenetic Historyen_US
dc.subjectEarly Holoceneen_US
dc.subjectCanimar Abajoen_US
dc.subjectOriginen_US
dc.subjectRadiocarbonen_US
dc.titleTen millennia of hepatitis B virus evolutionen_US
dc.typeArticleen_US

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