The effect of a multispecies synbiotic mixture on the duration of diarrhea and length of hospital stay in children with acute diarrhea in Turkey: Single blinded randomized study

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dc.authoridDinleyici, Ener Cagri/0000-0002-0339-0134
dc.authoridEren, Makbule/0000-0002-7105-7165
dc.authoridKara, Ates/0000-0002-1654-3232
dc.authoridOzen, Metehan/0000-0003-4088-3103
dc.contributor.authorDinleyici, Ener Cagri
dc.contributor.authorDalgic, Nazan
dc.contributor.authorGuven, Sirin
dc.contributor.authorOzen, Metehan
dc.contributor.authorKara, Ates
dc.contributor.authorArica, Vefik
dc.contributor.authorMetin-Timur, Ozge
dc.date.accessioned2024-09-18T20:59:14Z
dc.date.available2024-09-18T20:59:14Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractProbiotics have been successfully used for the treatment of acute diarrhea in children and this effect depends on the strains and dose. The aim of this study was to assess the effect of a synbiotic mixture on the duration of diarrhea and the length of hospital stay in children with acute watery diarrhea. This is a prospective randomized, multicenter single blinded clinical trial in hospitalized children with acute watery diarrhea. All children were treated with conventional hydration therapy with or without a daily dose of a synbiotic (2.5 x 10(9) CFU live bacteria including Lactobacillus acidophilus, Lactobacillus rhamnosus, Bifidobacterium bifidum, Bifidobacterium longum, Enterococcus faecium, and 625 mg fructooligosaccharide) for 5 days. The primary endpoint was duration of diarrhea and duration of hospitalization was the secondary endpoint. Among 209 eligible children, 113 received the synbiotic mixture and 96 served as a control. The duration of diarrhea was significantly shorter (similar to 36 h) in children receiving the synbiotic group than the controls (77.9 +/- 30.5 vs. 114.6 +/- 37.4 h, p < 0.0001). The duration of hospitalization was shorter in children receiving the synbiotic group (4.94 +/- 1.7 vs. 5.77 +/- 1.97 days, p = 0.002). The effect of synbiotic mixture on diarrhea started after 24th hours and stool frequency significantly decreased after 24th and 48th hours. The percentage of diarrhea-free children is significantly higher in synbiotic group at 48th and 72nd hours of synbiotic group. In conclusion, this study showed a reduction in diarrhea duration by approximately 36 h and a reduction in the duration of hospitalization with approximately 1 day in children with acute diarrhea with this synbiotic mixture.en_US
dc.identifier.doi10.1007/s00431-012-1903-5
dc.identifier.endpage464en_US
dc.identifier.issn0340-6199
dc.identifier.issn1432-1076
dc.identifier.issue4en_US
dc.identifier.pmid23239048en_US
dc.identifier.scopus2-s2.0-84876666212en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage459en_US
dc.identifier.urihttps://doi.org/10.1007/s00431-012-1903-5
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12465
dc.identifier.volume172en_US
dc.identifier.wosWOS:000316682700004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSynbioticen_US
dc.subjectProbioticen_US
dc.subjectDiarrheaen_US
dc.subjectHospitalizationen_US
dc.subjectChildrenen_US
dc.titleThe effect of a multispecies synbiotic mixture on the duration of diarrhea and length of hospital stay in children with acute diarrhea in Turkey: Single blinded randomized studyen_US
dc.typeArticleen_US

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