Fibrosis Marker Soluble ST2 Predicts Atrial Fibrillation Recurrence after Cryoballoon Catheter Ablation of Nonvalvular Paroxysmal Atria Fibrillation

Basit Öğe Kaydı
dc.authoridOkar, Sefa/0000-0003-1413-7393
dc.contributor.authorOkar, Sefa
dc.contributor.authorKaypakli, Onur
dc.contributor.authorSahin, Durmus Yildiray
dc.contributor.authorKoc, Mevlut
dc.date.accessioned2024-09-18T20:57:10Z
dc.date.available2024-09-18T20:57:10Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground and Objectives: We aimed to investigate the relationship between the recurrence of atrial fibrillation (AF) and fibrosis marker soluble ST2 (sST2) in patients with nonvalvular paroxysmal AF (PAF). Methods: We prospectively included 100 consecutive patients with PAF diagnosis and scheduled for cryoballoon catheter ablation for AF (47 males, 53 females; mean age 55.1 +/- 10.8 years). sST2 plasma levels were determined using the ASPECT-PLUS assay on ASPECT Reader device (Critical Diagnostics). The measurement range of these measurements was 12.5-250 ng/mL. Patients had regular follow-up visits with 12-lead electrocardiogram (ECG), medical history, and clinical evaluation. Twenty-four hours Hotter ECG monitoring had been recorded 12 months after ablation. Results: AF recurrence was detected in 22 patients after 1 year. Age, smoking history, diabetes mellitus,hypertension frequency, angiotensin converting enzyme inhibitor-angiotensin receptor blocker use, CHA(2)DS(2)VASc and HAS-BLED scores, serum sST2 level, left atrium (LA) end-diastolic diameter, LA volume and LA volume index were related to AF recurrence. In multivariable logistic regression analysis, sST2 was found to be only independent parameter for predicting AF recurrence (odds ratio, 1.085; p=0.001). Every 10-unit increase in sST2 was found to be associated with 2.103-fold increase in the risk of AF recurrence. The cut-off value of sST2 obtained by receiver operating characteristic curve analysis was 30.6 ng/mL for prediction of AF recurrence (sensitivity: 77.3%, specificity: 79.5%). The area under the curve was 0.831 (p<0.001). Conclusions: sST2, which is associated with atrial fibrosis, can be thought to be a useful marker for detection of patients with high-grade fibrosis who will get less benefit from cryoablation.en_US
dc.identifier.doi10.4070/kcj.2018.0047
dc.identifier.endpage929en_US
dc.identifier.issn1738-5520
dc.identifier.issn1738-5555
dc.identifier.issue10en_US
dc.identifier.pmid30238709en_US
dc.identifier.scopus2-s2.0-85053907963en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage920en_US
dc.identifier.urihttps://doi.org/10.4070/kcj.2018.0047
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12322
dc.identifier.volume48en_US
dc.identifier.wosWOS:000450735300006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Soc Cardiologyen_US
dc.relation.ispartofKorean Circulation Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSoluble ST2en_US
dc.subjectAF recurrenceen_US
dc.subjectCryosurgeryen_US
dc.titleFibrosis Marker Soluble ST2 Predicts Atrial Fibrillation Recurrence after Cryoballoon Catheter Ablation of Nonvalvular Paroxysmal Atria Fibrillationen_US
dc.typeArticleen_US

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