In vitro investigation of the genotoxic and cytotoxic effects of thiacloprid in cultured human peripheral blood lymphocytes

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dc.contributor.authorKocaman, Ayse Yavuz
dc.contributor.authorRencuzogullari, Eyyup
dc.contributor.authorTopaktas, Mehmet
dc.date.accessioned2024-09-18T20:26:52Z
dc.date.available2024-09-18T20:26:52Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThiacloprid, a neonicotinoid insecticide, is widely used for controlling various species of pests on many crops. The potential genotoxic effects of thiacloprid on human peripheral blood lymphocytes (PBLs) were investigated in vitro by the chromosome aberrations (CAs), sister chromatid exchanges (SCEs), and cytokinesis-block micronucleus (MN) assays. The human PBLs were treated with 75, 150, and 300 mu g/mL thiacloprid in the absence and presence of an exogenous metabolic activator (S9 mix). Thiacloprid increased the CAs and SCEs significantly at all concentrations (75, 150, and 300 mu g/mL) both in the absence and presence of the S9 mix and induced a significant increase in MN and nucleoplasmic bridge formations at all concentrations for 24 h and at 75 and 150 mu g/mL for 48-h treatment periods in the absence of the S9 mix; and at all concentrations in the presence of the S9 mix when compared with the control and solvent control. Thiacloprid was also found to significantly induce nuclear bud (NBUD) formation at 300 mu g/mL for 24 h and at 150 mu g/mL for 48-h treatment times in the absence of the S9 mix and at the two highest concentrations (150 and 300 mu g/mL) in the presence of the S9 mix. Thiacloprid significantly decreased the mitotic index, proliferation index, and nuclear division index for all concentrations both in the absence and presence of the S9 mix. (c) 2012 Wiley Periodicals, Inc. Environ Toxicol 29: 631-641, 2014.en_US
dc.description.sponsorshipMustafa Kemal University Research Fund [09F0101]en_US
dc.description.sponsorshipContract grant sponsor: Mustafa Kemal University Research Fund. Contract grant number: 09F0101.en_US
dc.identifier.doi10.1002/tox.21790
dc.identifier.endpage641en_US
dc.identifier.issn1520-4081
dc.identifier.issn1522-7278
dc.identifier.issue6en_US
dc.identifier.pmid22730181en_US
dc.identifier.scopus2-s2.0-84898916231en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage631en_US
dc.identifier.urihttps://doi.org/10.1002/tox.21790
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10572
dc.identifier.volume29en_US
dc.identifier.wosWOS:000334299500004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEnvironmental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthuman peripheral blood lymphocytesen_US
dc.subjectsister chromatid exchangeen_US
dc.subjectthiaclopriden_US
dc.subjectmicronucleusen_US
dc.subjectchromosome aberrationen_US
dc.titleIn vitro investigation of the genotoxic and cytotoxic effects of thiacloprid in cultured human peripheral blood lymphocytesen_US
dc.typeArticleen_US

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