What is the Optimal Time Period for Postponing Nephrectomy in Patients with Renal Cell Carcinoma of Various Stages?

Basit Öğe Kaydı
dc.authoridCelik, Serdar/0000-0003-0939-9989
dc.authoridBaltaci, Sumer/0000-0002-7604-841X
dc.authoridIzol, Volkan/0000-0001-5007-6781
dc.authoridBAYAZIT, YILDIRIM/0000-0001-7598-9667
dc.contributor.authorCelik, Serdar
dc.contributor.authorTinay, Iker
dc.contributor.authorSozen, Sinan
dc.contributor.authorOzen, Haluk
dc.contributor.authorAkdogan, Bulent
dc.contributor.authorAslan, Gueven
dc.contributor.authorBaltaci, Suemer
dc.date.accessioned2024-09-18T20:32:57Z
dc.date.available2024-09-18T20:32:57Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Ãœniversitesien_US
dc.description.abstractObjective: The coronavirus disease-2019 pandemic has shown us that postponing elective surgeries that include nephrectomy due to renal cell carcinomas (RCC) was undertaken by the physicians to use hospital facilities in a balanced way. However, both urologists and patients were concerned about postponements that may increase the risk of progression. To determine the optimal threshold of postponement time-period for surgery (PTP) and according to the clinical T stages in patients who underwent nephrectomy due to RCC, we used the Urologic Cancer Database-Kidney.Materials and Methods: Patients who underwent detailed clinical T stage analysis with admission and surgery dates were included in the study. PTP was calculated using the dates of definitive preoperative diagnosis and surgery date. Recurrence, overall mortality (OM), recurrence-free survival, and overall survival (OS) were evaluated. The effects of PTP on oncological outcome according to tumor diameter and clinical T stages were also evaluated. We also analyzed the optimal cut-offs of PTP based on clinical T stages.Results: Among 3.258 patients, in the evaluation of 2.946 clinically localized patients, PTP and tumor diameter were found to be important predictors of recurrence (p=0.037 and p<0.001). The optimal PTP of 30 days was found to be an important significant threshold time for the T1 stage and 20 days for T2-4 stage tumors. Patients with longer PTP according to the thresholds shown in this study had higher upstaging for clinical T1a, T2a, and T3 stages; higher recurrence rates for T1b and T2b stages; and higher OM for T2a and T3 tumors. The survival have also shown that more than 20 days of PTP affected OSs for clinical-stage T1 (p=0.019), T2 (p=0.021) and T3 (p=0.007) tumors.Conclusions: All patients with tumors, including clinical T1 tumors, had worsening oncological results as the PTP increased (>20-30 days).en_US
dc.identifier.doi10.4274/uob.galenos.2022.2022.10.2
dc.identifier.endpage155en_US
dc.identifier.issn2147-2270
dc.identifier.issue4en_US
dc.identifier.startpage150en_US
dc.identifier.urihttps://doi.org/10.4274/uob.galenos.2022.2022.10.2
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11230
dc.identifier.volume22en_US
dc.identifier.wosWOS:001117734200005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofUroonkoloji Bulteni-Bulletin of Urooncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMortalityen_US
dc.subjectnephrectomyen_US
dc.subjectoverall survivalen_US
dc.subjectpostponement time-period for surgery (PTP)en_US
dc.subjectrecurrence free survivalen_US
dc.subjectrenal cell carcinoma (RCC)en_US
dc.titleWhat is the Optimal Time Period for Postponing Nephrectomy in Patients with Renal Cell Carcinoma of Various Stages?en_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
Ä°sim:
Tam Metin / Full Text
Boyut:
387.88 KB
Biçim:
Adobe Portable Document Format
Ä°ndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu