Antioxidant and anti-inflammatory activities of Gallic acid in Japanese quails induced by oxidative stress

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dc.authoridALASAHAN, SEMA/0000-0002-1144-7786
dc.contributor.authorIsgor, Mehmet Mustafa
dc.contributor.authorKucukgul, Altug
dc.contributor.authorAlasahan, Sema
dc.date.accessioned2024-09-18T20:25:16Z
dc.date.available2024-09-18T20:25:16Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractGallic acid is a phenolic compound found in many plant sources with strong antioxidant activity. In this study, the bioactivity of Gallic acid was investigated in Japanese quails induced by oxidative stress. The study was performed on four groups of 40-day-old male Japanese quail (Coturnix japonica). Oxidative stress was created for 1 week by adding 0.5% hydrogen peroxide. The study was terminated by administering 100 mg center dot kg(-1) body weight Gallic acid intraperitoneally. Total antioxidant and total oxidant level analyzes from liver tissue homogenates were performed using a ready-made commercial kit. TNF-alpha levels from blood samples taken for anti-inflammatory activity were investigated by ELISA method. There were no statistically significant results on live weight gain between the experimental groups and control group. However, Gallic acid in liver homogenates together with H2O2 increased total antioxidant state (TAS) compared to H2O2 application, while it decreased total oxidant state (TOS) in the same groups. Moreover, while the oxidative stress index increased in the H2O2 group, it decreased significantly in both the Gallic acid and Gallic acid + H2O2 groups. Gallic acid application also caused regression in blood TNF-alpha expression levels, which were increased by H2O2. In quails, Gallic acid showed antioxidant activity by increasing TAS levels and decreasing TOS levels, providing a significant decrease in oxidative stress index. It also provided anti-inflammatory activity by suppressing TNF-alpha levels. However, advanced molecular analyzes are needed to obtain more detailed information on the subject.en_US
dc.identifier.doi10.52973/rcfcv-e33258
dc.identifier.issn0798-2259
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85172904311en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.52973/rcfcv-e33258
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10205
dc.identifier.volume33en_US
dc.identifier.wosWOS:001069703500011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniv Zulia, Facultad Ciencias Veterinariasen_US
dc.relation.ispartofRevista Cientifica-Facultad De Ciencias Veterinariasen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGallic aciden_US
dc.subjectgrowth performanceen_US
dc.subjectoxidative stressen_US
dc.subjectinflammationen_US
dc.subjectquailsen_US
dc.titleAntioxidant and anti-inflammatory activities of Gallic acid in Japanese quails induced by oxidative stressen_US
dc.typeArticleen_US

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